Detailed information of TA system TA225982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2622892..2623478
• Replicon: chromosome
• Accession: NZ_CP087681
• Organism: Xylella taiwanensis strain PLS1133

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH45_RS10935
• Protein ID: WP_038273324.1
• Coordinates: 2623224..2623478 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH45_RS10930
• Protein ID: WP_038273322.1
• Coordinates: 2622892..2623227 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH45_RS10905 (LPH45_10905)	2618320..2619528	+	1209	WP_038272829.1	hypothetical protein	-
LPH45_RS10910 (LPH45_10910)	2620030..2620350	-	321	WP_038272832.1	hypothetical protein	-
LPH45_RS10915 (LPH45_10915)	2620422..2621138	-	717	WP_160165226.1	portal protein	-
LPH45_RS10920 (LPH45_10920)	2621135..2622241	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH45_RS10925 (LPH45_10925)	2622238..2622639	-	402	WP_114867107.1	lysozyme	-
LPH45_RS10930 (LPH45_10930)	2622892..2623227	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH45_RS10935 (LPH45_10935)	2623224..2623478	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH45_RS10940 (LPH45_10940)	2623580..2624278	-	699	WP_114867108.1	hypothetical protein	-
LPH45_RS10945 (LPH45_10945)	2624235..2625428	+	1194	WP_230428203.1	hypothetical protein	-
LPH45_RS10950 (LPH45_10950)	2625432..2625704	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH45_RS10955 (LPH45_10955)	2625706..2626056	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH45_RS10960 (LPH45_10960)	2626132..2627478	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH45_RS10965 (LPH45_10965)	2627493..2628377	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2620422..2636333	15911

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T225982 WP_038273324.1 NZ_CP087681:c2623478-2623224 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T225982 NZ_CP121647:3419535-3419819 [Bradyrhizobium sp. CB3481]
ATGATCGTCAGCTATCGGGACAAGCGCACGGAGCGGTTTGCCTCAGGACGTCACGTCAAGGAGTTCTCCGGCTTCGCGCG
ACAGGCCGAGATGCGGCTTGATCGACTGGACGCAGCGACCAGCCTGGCTGATTTGGCTGCGCTGCCCGGCAACCGTCTGG
AAGCACTCAGAGGCGATCGCGCTGGATTGTATTCGATCCGCATCAATGATCAGTGGCGAATATGCTTTGCCTGGCCGGAA
GGATCATCCGGTCCGATAGAGGTAGAGATCGTCGATTATCACTAG

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT225982 WP_038273322.1 NZ_CP087681:c2623227-2622892 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT225982 NZ_CP121647:3419832-3420143 [Bradyrhizobium sp. CB3481]
ATGCCTCGCTCACCCATTCATCCCGGCGAACATCTCGCTGAAGAGCTGAACGAGCTTGGAATCACCGCTGCGGAACTGTC
GCGTCAGATCGACGTGCCGGTAAACCGGATTACCGGCATCATTCACGGTCAGCGCGGCATCACCGCCGACACCGCACTGC
GCCTGGGGCACTGGTTTGGCAACAGCCCGCAATTCTGGATGAACCTGCAGCAGCTCTACGAATTGCGTCTTGCTGAAAAT
GAAGTTGGTGCGGAAATCGCAGCGTTGCCGCGCCGCGCCGGTCGAACGGCGTCGCGCCAGGGCAGGAGCTAG

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5