Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1021459..1022051 | Replicon | chromosome |
| Accession | NC_010161 | ||
| Organism | Bartonella tribocorum CIP 105476 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A9ISY3 |
| Locus tag | BTR_RS04550 | Protein ID | WP_012231574.1 |
| Coordinates | 1021851..1022051 (-) | Length | 67 a.a. |
Antitoxin (Protein)
| Gene name | hicA | Uniprot ID | A9ISY1 |
| Locus tag | BTR_RS04545 | Protein ID | WP_012231571.1 |
| Coordinates | 1021459..1021854 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BTR_RS12230 | 1016900..1017198 | + | 299 | Protein_838 | BrnT family toxin | - |
| BTR_RS04505 | 1017185..1017457 | + | 273 | WP_012231561.1 | BrnA antitoxin family protein | - |
| BTR_RS04510 | 1017499..1017797 | + | 299 | Protein_840 | type II toxin-antitoxin system HicB family antitoxin | - |
| BTR_RS04515 | 1017870..1018151 | + | 282 | WP_012231565.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| BTR_RS04520 | 1018167..1018454 | + | 288 | WP_007346872.1 | HigA family addiction module antidote protein | - |
| BTR_RS04525 | 1018499..1018777 | - | 279 | WP_012231568.1 | hypothetical protein | - |
| BTR_RS04530 | 1018774..1019487 | - | 714 | WP_012231569.1 | phage antirepressor Ant | - |
| BTR_RS04535 | 1020083..1020661 | - | 579 | WP_012231073.1 | hypothetical protein | - |
| BTR_RS04540 | 1020665..1020985 | - | 321 | WP_012231570.1 | hypothetical protein | - |
| BTR_RS04545 | 1021459..1021854 | - | 396 | WP_012231571.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| BTR_RS04550 | 1021851..1022051 | - | 201 | WP_012231574.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| BTR_RS04555 | 1022116..1022652 | - | 537 | WP_012231576.1 | hypothetical protein | - |
| BTR_RS04560 | 1022663..1023109 | - | 447 | WP_038473476.1 | single-stranded DNA-binding protein | - |
| BTR_RS04565 | 1023350..1023541 | + | 192 | WP_038473479.1 | hypothetical protein | - |
| BTR_RS04570 | 1023611..1024039 | + | 429 | WP_012231580.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| BTR_RS04575 | 1024088..1024636 | - | 549 | WP_012231582.1 | antA/AntB antirepressor family protein | - |
| BTR_RS04580 | 1024850..1025227 | - | 378 | WP_012231584.1 | hypothetical protein | - |
| BTR_RS04585 | 1025389..1025808 | - | 420 | WP_012231586.1 | hypothetical protein | - |
| BTR_RS04590 | 1025801..1026904 | - | 1104 | WP_012231587.1 | DUF1376 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1012482..1094562 | 82080 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 67 a.a. Molecular weight: 7493.75 Da Isoelectric Point: 10.7918
>T22598 WP_012231574.1 NC_010161:c1022051-1021851 [Bartonella tribocorum CIP 105476]
MEQNSRKIIAKLKRDGFELVKVKGSHHKFEKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
MEQNSRKIIAKLKRDGFELVKVKGSHHKFEKDGKVVIVPHPKKNLPIGTARSIAQQAGWFKKGEEE
Download Length: 201 bp
>T22598 NC_010161:c1022051-1021851 [Bartonella tribocorum CIP 105476]
ATGGAACAAAACAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTAAAAGTAAAAGGTTCGCACCA
TAAATTTGAAAAAGACGGTAAGGTTGTTATTGTTCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA
ATGGAACAAAACAGCCGAAAGATAATTGCAAAATTAAAACGCGATGGCTTTGAACTTGTAAAAGTAAAAGGTTCGCACCA
TAAATTTGAAAAAGACGGTAAGGTTGTTATTGTTCCACATCCTAAAAAAAATCTTCCAATTGGTACAGCGCGTTCTATTG
CACAACAAGCAGGCTGGTTTAAAAAAGGAGAAGAAGAATGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14734.71 Da Isoelectric Point: 4.3191
>AT22598 WP_012231571.1 NC_010161:c1021854-1021459 [Bartonella tribocorum CIP 105476]
MKRFFALVHKDEDSAFGVQFPDFEGLFSASDEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
MKRFFALVHKDEDSAFGVQFPDFEGLFSASDEEENLIINATEALQLYCEDMDTVPVPLKFEEVIQQKAVKKALSEGAFLI
QVPFIENDSEVVRTNISIERGLLRAIDNCAQERGLTRSAFLATAARHELNI
Download Length: 396 bp
>AT22598 NC_010161:c1021854-1021459 [Bartonella tribocorum CIP 105476]
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTTCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTACAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCCTTGTCAGAAGGAGCTTTTTTAATA
CAAGTTCCTTTTATTGAAAATGATTCAGAAGTCGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGCTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG
ATGAAAAGATTTTTTGCTCTTGTTCATAAAGATGAGGATTCTGCTTTTGGTGTTCAATTTCCTGATTTTGAAGGTCTATT
CTCTGCTTCTGATGAAGAAGAAAATCTTATCATAAATGCAACCGAAGCTTTACAACTTTACTGTGAAGATATGGATACAG
TGCCTGTTCCTTTAAAATTTGAAGAAGTGATACAACAGAAAGCTGTCAAAAAAGCCTTGTCAGAAGGAGCTTTTTTAATA
CAAGTTCCTTTTATTGAAAATGATTCAGAAGTCGTACGTACAAATATATCAATTGAACGAGGGCTTTTGCGTGCAATTGA
TAATTGTGCACAAGAGAGAGGCTTAACAAGATCTGCTTTTTTGGCAACAGCAGCCCGTCACGAGCTTAATATTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|