Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 8698..9239 | Replicon | chromosome |
| Accession | NZ_CP087681 | ||
| Organism | Xylella taiwanensis strain PLS1133 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Z9JGT1 |
| Locus tag | LPH45_RS00095 | Protein ID | WP_038273166.1 |
| Coordinates | 8916..9239 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Z9JGL9 |
| Locus tag | LPH45_RS00090 | Protein ID | WP_038273164.1 |
| Coordinates | 8698..8919 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH45_RS00040 (LPH45_00040) | 4274..4510 | - | 237 | WP_230428212.1 | major capsid protein | - |
| LPH45_RS00045 (LPH45_00045) | 4519..4725 | - | 207 | WP_038273075.1 | hypothetical protein | - |
| LPH45_RS00050 (LPH45_00050) | 4728..5042 | - | 315 | WP_230428211.1 | hypothetical protein | - |
| LPH45_RS00055 (LPH45_00055) | 5318..5905 | - | 588 | WP_038273076.1 | hypothetical protein | - |
| LPH45_RS00060 (LPH45_00060) | 6102..6245 | - | 144 | WP_160165233.1 | hypothetical protein | - |
| LPH45_RS00065 (LPH45_00065) | 6365..6565 | - | 201 | WP_038273077.1 | hypothetical protein | - |
| LPH45_RS00070 (LPH45_00070) | 6614..6877 | - | 264 | WP_162814095.1 | hypothetical protein | - |
| LPH45_RS00075 (LPH45_00075) | 6881..7042 | - | 162 | WP_160165236.1 | hypothetical protein | - |
| LPH45_RS00080 (LPH45_00080) | 7332..7661 | + | 330 | WP_230428286.1 | DUF3693 domain-containing protein | - |
| LPH45_RS00085 (LPH45_00085) | 7750..8250 | - | 501 | Protein_16 | tyrosine-type recombinase/integrase | - |
| LPH45_RS00090 (LPH45_00090) | 8698..8919 | + | 222 | WP_038273164.1 | antitoxin MazE family protein | Antitoxin |
| LPH45_RS00095 (LPH45_00095) | 8916..9239 | + | 324 | WP_038273166.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LPH45_RS00100 (LPH45_00100) | 9340..10488 | - | 1149 | WP_069636227.1 | zonular occludens toxin domain-containing protein | - |
| LPH45_RS00105 (LPH45_00105) | 10488..10829 | - | 342 | WP_038273089.1 | DUF2523 family protein | - |
| LPH45_RS00110 (LPH45_00110) | 10833..11900 | - | 1068 | WP_152536670.1 | virulence factor TspB C-terminal domain-related protein | - |
| LPH45_RS00115 (LPH45_00115) | 12368..12586 | - | 219 | WP_051482398.1 | major capsid protein | - |
| LPH45_RS00120 (LPH45_00120) | 12595..12804 | - | 210 | WP_230428208.1 | hypothetical protein | - |
| LPH45_RS00125 (LPH45_00125) | 12804..13097 | - | 294 | WP_038273093.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 221..16474 | 16253 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11807.97 Da Isoelectric Point: 9.1188
>T225979 WP_038273166.1 NZ_CP087681:8916-9239 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
Download Length: 324 bp
>T225979 NZ_CP121642:2522460-2522846 [Rhizobium sp. CC1099]
ATGGTGATCGATACCTCTGCGATTGTCGCGATCCTGCGCAGTGAACCAGAGGCCGCAACGCTCGAGAGAACGGTCGTCGC
CAACCCTATTCGTTTGGTCCCCGCGACATGTGTTCTTGAGACGCGTATGGTCTTGGTCAGCCGGCGCGGCGAACACGCAC
TTGCCGAGATCGATCTGTGGCTCGCCAGAATCGAGGCCGACATCGTTCCGGTCGACGCCGATCTGGTGGATCTGGCGACA
CAGGCCTGGCTTACTTACGGCAAGGGCCGCCATCCGGCGGCATTGAATTTTGCCGATTGTTTTTCCTACGCTTTGGCAAA
GCGTGCGGACGAACCGCTTCTCTTCATCGGCGAGGACTTTTCGCGCACCGATATCGAGGCGGCATAA
ATGGTGATCGATACCTCTGCGATTGTCGCGATCCTGCGCAGTGAACCAGAGGCCGCAACGCTCGAGAGAACGGTCGTCGC
CAACCCTATTCGTTTGGTCCCCGCGACATGTGTTCTTGAGACGCGTATGGTCTTGGTCAGCCGGCGCGGCGAACACGCAC
TTGCCGAGATCGATCTGTGGCTCGCCAGAATCGAGGCCGACATCGTTCCGGTCGACGCCGATCTGGTGGATCTGGCGACA
CAGGCCTGGCTTACTTACGGCAAGGGCCGCCATCCGGCGGCATTGAATTTTGCCGATTGTTTTTCCTACGCTTTGGCAAA
GCGTGCGGACGAACCGCTTCTCTTCATCGGCGAGGACTTTTCGCGCACCGATATCGAGGCGGCATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8490.65 Da Isoelectric Point: 8.0827
>AT225979 WP_038273164.1 NZ_CP087681:8698-8919 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
Download Length: 222 bp
>AT225979 NZ_CP121642:2522203-2522460 [Rhizobium sp. CC1099]
ATGTCGCTCAATATCAAAAACCCCGCCACAGTCGCTCTCGTTGACGAGCTTGCGCGGCGGCAAGGTATCAGCAAGACCGC
AGCCATTCATCAGGCTTTGACGGAGCGTCTACATCGCATGGGATACGGCGATGTGGCGCAGGAGCGTCTGCTCACCGAGA
TACAGGCGATCCGTGGGCGAGTGGCGCGATTGCCCGAACTCGACAGCCGAAGCGATGAAGAAATCATCGGCTACGATGAG
CATGGAATTCCGAACTGA
ATGTCGCTCAATATCAAAAACCCCGCCACAGTCGCTCTCGTTGACGAGCTTGCGCGGCGGCAAGGTATCAGCAAGACCGC
AGCCATTCATCAGGCTTTGACGGAGCGTCTACATCGCATGGGATACGGCGATGTGGCGCAGGAGCGTCTGCTCACCGAGA
TACAGGCGATCCGTGGGCGAGTGGCGCGATTGCCCGAACTCGACAGCCGAAGCGATGAAGAAATCATCGGCTACGATGAG
CATGGAATTCCGAACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|