Detailed information of TA system TA225975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 972815..973209
• Replicon: chromosome
• Accession: NZ_CP087680
• Organism: Xylella taiwanensis strain PLS407

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH41_RS04525
• Protein ID: WP_200866186.1
• Coordinates: 973006..973209 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH41_RS04520
• Protein ID: WP_038270756.1
• Coordinates: 972815..973009 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH41_RS04490 (LPH41_04490)	968645..969482	-	838	Protein_881	VirB8/TrbF family protein	-
LPH41_RS04495 (LPH41_04495)	969658..970787	+	1130	Protein_882	DUF5710 domain-containing protein	-
LPH41_RS04500 (LPH41_04500)	971057..971338	-	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH41_RS04505 (LPH41_04505)	971450..971533	-	84	Protein_884	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH41_RS04510 (LPH41_04510)	971667..972047	-	381	WP_038270750.1	hypothetical protein	-
LPH41_RS04515 (LPH41_04515)	972176..972571	-	396	WP_230428271.1	DUF4158 domain-containing protein	-
LPH41_RS04520 (LPH41_04520)	972815..973009	+	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH41_RS04525 (LPH41_04525)	973006..973209	+	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH41_RS04530 (LPH41_04530)	973344..973958	+	615	WP_230428270.1	recombinase family protein	-
LPH41_RS04535 (LPH41_04535)	974031..975422	-	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH41_RS04540 (LPH41_04540)	976658..977668	+	1011	WP_038270757.1	serine protease	-
LPH41_RS04545 (LPH41_04545)	978055..978195	-	141	WP_160165149.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T225975 WP_200866186.1 NZ_CP087680:973006-973209 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T225975 NZ_CP121642:c1371043-1370537 [Rhizobium sp. CC1099]
ATGCCTGAGACCGTCGTGCATCTATGGCGCGCCTTCGTTCCACGATGGGCCCATGCGCCGCTTTCTGGCGAGGGCGCCAG
CCGTTTTGGTGGCCGGTGGAATCGGGTGGGTGCCCCGACCATCTATGCGGCCTGCGAGCTGTCCACGGCCTGGGCCGAAT
ATAACCAGGGCTTTGTTCAGCACCCGGCGATGATCGTGCAATTGGAACTCAAAGGGGCGCGCCTCGCGGACACGACCGAC
CAGATGCTTCTTCGAAAGTTTGACGTTACTGCGGATATCTATCGTTGCGAATGGCGGATGCTGATGGATGAAAGCAAGGT
GCCGGCAACCCACCACCTGCGCGAACGTCTGATTGCATCGCGATATCATGGCGCGATCTATCCATCTTTCATGTCGCTCG
GCGGCACATGCGTCGCGCTGTGGGAATGGAATATGCCGGGTGCACCGGAGCTTCGCGCAATCGATCCAGATGGTCGACTG
CCCAAATCACCGGCCTCCTGGTTGTAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT225975 WP_038270756.1 NZ_CP087680:972815-973009 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT225975 NZ_CP121642:c1371407-1371036 [Rhizobium sp. CC1099]
ATGGCAGCCACAGGCCTCAGCAATGTCGCTGCTCGCTTCGGCGATGAACATTCGTCGTTTCTATCGGCCCGGCGCGTCGC
CGAGCAACTGGGCGTAACGCTCTCCGAGCTAGCCCGGCTGATCGGGGTTGCGCGCAATACGCTGGCGGCGAAATCGGGCG
CCCGCAAAGTGGATAATGCGCTGAGCAACGTCGTCCGCATCCTTGCGATGGCAAGCGAAATGGCCGGCGACGAAAACCGT
GCGGTCATATGGTTCAAGCATCAGCCGATCCCCGGTTGGGGCGGCAAGACGGCGTTTGACCTTGTCGGCGAAGGCAAGTC
CGACCGGGTTCTCGCCTATCTCGAGGCCGTCCGCTCCGGCGTCTATGCCTGA

Structures

Antitoxin

• AlphaFold DB: Z9JJI0