Detailed information of TA system TA225973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 166498..167084
• Replicon: chromosome
• Accession: NZ_CP087680
• Organism: Xylella taiwanensis strain PLS407

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH41_RS00870
• Protein ID: WP_038273324.1
• Coordinates: 166498..166752 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH41_RS00875
• Protein ID: WP_038273322.1
• Coordinates: 166749..167084 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH41_RS00840 (LPH41_00840)	161599..162483	-	885	WP_114867111.1	hypothetical protein	-
LPH41_RS00845 (LPH41_00845)	162498..163844	-	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH41_RS00850 (LPH41_00850)	163920..164270	+	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH41_RS00855 (LPH41_00855)	164272..164544	-	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH41_RS00860 (LPH41_00860)	164548..165741	-	1194	WP_230439301.1	hypothetical protein	-
LPH41_RS00865 (LPH41_00865)	165698..166396	+	699	WP_114867108.1	hypothetical protein	-
LPH41_RS00870 (LPH41_00870)	166498..166752	+	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH41_RS00875 (LPH41_00875)	166749..167084	+	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH41_RS00880 (LPH41_00880)	167337..167738	+	402	WP_114867107.1	lysozyme	-
LPH41_RS00885 (LPH41_00885)	167759..168139	+	381	WP_230439302.1	phage terminase large subunit	-
LPH41_RS00890 (LPH41_00890)	168087..168842	+	756	WP_230439303.1	hypothetical protein	-
LPH41_RS00895 (LPH41_00895)	168839..169555	+	717	WP_160165226.1	portal protein	-
LPH41_RS00900 (LPH41_00900)	169627..169947	+	321	WP_038272832.1	hypothetical protein	-
LPH41_RS00905 (LPH41_00905)	170449..171657	-	1209	WP_038272829.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	153646..169555	15909

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T225973 WP_038273324.1 NZ_CP087680:166498-166752 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T225973 NZ_CP121641:703465-703830 [Rhizobium sp. CC1099]
ATGGTGAAAGCGCTCTTCGATACGAACATCCTTATCGACTACCTCAACGCCATACCGGAAGCCCGCGACGAGCTTGACCG
CTATGGACGCCGTGCCATCAGCGTCGTCACTTGGATGGAGGTGTTGATTGGCGCTGATCCCGACGTCGAAGCAGCGACGC
GAAGCTTCTTGAATAACTTCCAGATCATCGCGGTTGATAATGTGATAGCGGAAGGCGCTGTTCGCTTAAGACAGCACCAC
CGGATCAAATTGCCGGACGCGATAATCTGGTCGACCGCCGATGCGCATGCGTCGCTCCTGGTGACGCGCAACACCAAGGA
CTTTCCGGCGGATAATCCTGGAATCCGCGTCCCATATCTGCGTTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT225973 WP_038273322.1 NZ_CP087680:166749-167084 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT225973 NZ_CP121641:703256-703471 [Rhizobium sp. CC1099]
ATGCGTATCCTGGTCGATATCGTCGAATCCGAGTTGAAGGCGCTGGATAAGATGGCGAAGAGCGAGAAGGTTTCCCGCGC
CTCGCTCATCCGCAAAGCTGTCAACGATTTTCTGGATCGTCATGATCGGACAAAAGAGGCAGAAGCTTTCGGGCTCTGGG
GTAATAGAAAGATCGATGGGCTCGAATACCAGGATAAAGTTCGAAGCGAATGGTGA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5