Detailed information of TA system TA225970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2792790..2793475
• Replicon: chromosome
• Accession: NZ_CP087678
• Organism: Xylella taiwanensis strain PLS206

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LPH42_RS11790
• Protein ID: WP_038272463.1
• Coordinates: 2793059..2793475 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LPH42_RS11785
• Protein ID: WP_038272460.1
• Coordinates: 2792790..2793062 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH42_RS11750 (LPH42_11750)	2788017..2788604	+	588	WP_038273076.1	hypothetical protein	-
LPH42_RS11755 (LPH42_11755)	2788880..2789194	+	315	WP_230428211.1	hypothetical protein	-
LPH42_RS11760 (LPH42_11760)	2789197..2789403	+	207	WP_038273075.1	hypothetical protein	-
LPH42_RS11765 (LPH42_11765)	2789412..2789648	+	237	WP_230428212.1	major capsid protein	-
LPH42_RS11770 (LPH42_11770)	2789828..2791213	+	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH42_RS11775 (LPH42_11775)	2791216..2791560	+	345	WP_038273069.1	DUF2523 family protein	-
LPH42_RS11780 (LPH42_11780)	2791573..2792700	+	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH42_RS11785 (LPH42_11785)	2792790..2793062	+	273	WP_038272460.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LPH42_RS11790 (LPH42_11790)	2793059..2793475	+	417	WP_038272463.1	type II toxin-antitoxin system VapC family toxin	Toxin
LPH42_RS11795 (LPH42_11795)	2793538..2793882	-	345	WP_038272464.1	DUF3653 domain-containing protein	-
LPH42_RS11800 (LPH42_11800)	2793873..2794118	-	246	WP_230428284.1	hypothetical protein	-
LPH42_RS11805 (LPH42_11805)	2794702..2795316	-	615	WP_081755477.1	HNH endonuclease	-
LPH42_RS11810 (LPH42_11810)	2795592..2796065	-	474	WP_038272510.1	LEA type 2 family protein	-
LPH42_RS11815 (LPH42_11815)	2796910..2798121	+	1212	WP_038272508.1	signal recognition particle-docking protein FtsY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2785921..2800345	14424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-52)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15195.91 Da
• Isoelectric Point: 6.9048

>T225970 WP_038272463.1 NZ_CP087678:2793059-2793475 [Xylella taiwanensis]
MSGYLLDTNIISDMIRNPFGLVACRIEKVDPKEVCTSIVVAAELRYGCAKKGSTKLLAKVKLMLETIPVLPLDIPTDAEY
GRIRAELESVGQTIGLNDLLIGTHAYVLGMTLVTDNVKEFKRIRGLKIENWLECASSV

Nucleotide

• Length: 417 bp

>T225970 NZ_CP121636:c621781-621398 [Rhizobium leguminosarum]
GTGATACTGGCAGACACTTCTATATGGATCGATCATTTCCGCCATGTTGATGCGGAACTTCGGACGATCATTGAGGACGA
TCGTCTACTCTGCCATCCGGCTGTAGTTGGCGAACTGGCGCTTGGCAGCCTTCGAGATCGCGGGCGCGTGATAGCGTTTC
TGGCAGCCCAGCGCCAAGCGTTCGTCGCAACGCATGACGAAGTGATGACAATGATTGATCGTCACGGCATTTTCAGTATG
GGCATCGGCTATACAGATGCCCACTTGCTCGCCTCGATACTGCTTGATCGGCGAGCGGCGTTATGGACCAGGGACAAGCG
TCTTCAGGCGGCGGCCAAAAAGGCAGGCGCTTCATTGCATAAGCCGGCCAATGCTCGCAACTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10331.95 Da
• Isoelectric Point: 4.5216

>AT225970 WP_038272460.1 NZ_CP087678:2792790-2793062 [Xylella taiwanensis]
MSISMPSSRLKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPVSMPTNIIELLAQWKTEDPLGLEDQFPEIE
DMLAKPDDIF

Nucleotide

• Length: 273 bp

>AT225970 NZ_CP121636:c621978-621778 [Rhizobium leguminosarum]
ATGCGATCGACTATCAATCTAGACGACACTCTCATGGAAAGGGCCAGGTCCCTGACCGGCACAAAAGAAACCGCTGCTAT
AGTCCGCCAGGCGTTGGAGACGCTTGTTCGAGTAGAGTCCGGAAAACGCCTCATCGCGCTCGGCGGAACTATGCCCGATG
CAGAGGCAGCTCCACGTCGCCGGAGCGCAGCTGCCAAGTGA