Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 562114..562673 Replicon chromosome
Accession NC_010161
Organism Bartonella tribocorum CIP 105476

Toxin (Protein)


Gene name parE Uniprot ID A9IPY8
Locus tag BTR_RS02585 Protein ID WP_012231080.1
Coordinates 562401..562673 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5B9CWB1
Locus tag BTR_RS02580 Protein ID WP_012231079.1
Coordinates 562114..562404 (+) Length 97 a.a.

Genomic Context

BTR_RS12170BTR_RS02560BTR_RS02570BTR_RS02575BTR_RS13090BTR_RS02580BTR_RS02585BTR_RS02590BTR_RS02550BTR_RS02555BTR_RS02565
Location: 558533..558715 (183 bp)
Type: Others
Protein ID: WP_038473319.1
Location: 558736..559158 (423 bp)
Type: Others
Protein ID: WP_012231075.1
Location: 559842..561008 (1167 bp)
Type: Others
Protein ID: WP_012231077.1
Location: 561209..561409 (201 bp)
Type: Others
Protein ID: WP_012231078.1
Location: 561507..561656 (150 bp)
Type: Others
Protein ID: WP_169309786.1
Location: 562114..562404 (291 bp)
Type: Antitoxin
Protein ID: WP_012231079.1
Location: 562401..562673 (273 bp)
Type: Toxin
Protein ID: WP_012231080.1
Location: 562920..563822 (903 bp)
Type: Others
Protein ID: Protein_479
Location: 557322..557900 (579 bp)
Type: Others
Protein ID: WP_012231073.1
Location: 557904..558218 (315 bp)
Type: Others
Protein ID: WP_012231074.1
Location: 559162..559668 (507 bp)
Type: Others
Protein ID: WP_081458154.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BTR_RS02550557322..557900-579WP_012231073.1hypothetical protein-
BTR_RS02555557904..558218-315WP_012231074.1hypothetical protein-
BTR_RS12170558533..558715+183WP_038473319.1type II toxin-antitoxin system HicA family toxin-
BTR_RS02560558736..559158+423WP_012231075.1hypothetical protein-
BTR_RS02565559162..559668-507WP_081458154.1hypothetical protein-
BTR_RS02570559842..561008+1167WP_012231077.1site-specific integrase-
BTR_RS02575561209..561409+201WP_012231078.1DNA-binding protein-
BTR_RS13090561507..561656+150WP_169309786.1hypothetical protein-
BTR_RS02580562114..562404+291WP_012231079.1hypothetical proteinAntitoxin
BTR_RS02585562401..562673+273WP_012231080.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
BTR_RS02590562920..563822+903Protein_479DUF3987 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--476132..594109117977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10612.57 Da        Isoelectric Point: 10.9313

>T22597 WP_012231080.1 NC_010161:562401-562673 [Bartonella tribocorum CIP 105476]
MKLIWTQVARVDRKKIREYISQNNPSAALKFDQLLSEKIEKLVKFSTLGRLGRVVNTREFIVHPNYIMIYDISDGVVRIL
RVLHTKQKFP

Download         Length: 273 bp

>T22597 NC_010161:562401-562673 [Bartonella tribocorum CIP 105476]
ATGAAGCTAATTTGGACACAAGTAGCACGCGTTGACCGCAAAAAGATACGTGAATACATATCACAAAATAATCCTTCTGC
TGCCTTAAAGTTTGATCAACTTTTATCTGAAAAGATAGAAAAACTCGTTAAGTTTTCTACTCTTGGTCGTTTAGGACGAG
TTGTAAATACACGTGAATTTATTGTACATCCAAATTATATCATGATTTATGATATTTCAGATGGCGTTGTTCGTATTTTA
CGTGTGCTTCATACAAAGCAAAAATTCCCTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11078.46 Da        Isoelectric Point: 5.2356

>AT22597 WP_012231079.1 NC_010161:562114-562404 [Bartonella tribocorum CIP 105476]
MAETTFTFRVDDVLKNEFSKAAKACDRSGAQLLRDYMRDIVKEQKERSAHDLWFREQVQLGINSANAGDIISSEEIEAEA
KEWRLKIQSKLDRSTL

Download         Length: 291 bp

>AT22597 NC_010161:562114-562404 [Bartonella tribocorum CIP 105476]
ATGGCTGAGACGACATTTACCTTTCGCGTTGATGATGTATTGAAAAATGAATTTTCCAAAGCAGCAAAAGCGTGTGATAG
ATCTGGTGCACAATTGTTGCGAGATTATATGCGCGATATCGTAAAAGAACAAAAAGAAAGAAGTGCACACGATTTATGGT
TTCGGGAACAGGTTCAATTAGGGATAAATTCTGCTAATGCAGGCGATATAATATCTTCTGAGGAAATCGAAGCAGAAGCA
AAGGAATGGCGCTTAAAAATACAAAGTAAACTAGATAGATCAACTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA9IPY8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5B9CWB1

References