22597

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 562114..562673 Replicon chromosome
Accession NC_010161
Organism Bartonella tribocorum CIP 105476

Toxin (Protein)


Gene name parE Uniprot ID A9IPY8
Locus tag BTR_RS02585 Protein ID WP_012231080.1
Coordinates 562401..562673 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5B9CWB1
Locus tag BTR_RS02580 Protein ID WP_012231079.1
Coordinates 562114..562404 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTR_RS02550 557322..557900 - 579 WP_012231073.1 hypothetical protein -
BTR_RS02555 557904..558218 - 315 WP_012231074.1 hypothetical protein -
BTR_RS12170 558533..558715 + 183 WP_038473319.1 type II toxin-antitoxin system HicA family toxin -
BTR_RS02560 558736..559158 + 423 WP_012231075.1 hypothetical protein -
BTR_RS02565 559162..559668 - 507 WP_081458154.1 hypothetical protein -
BTR_RS02570 559842..561008 + 1167 WP_012231077.1 site-specific integrase -
BTR_RS02575 561209..561409 + 201 WP_012231078.1 DNA-binding protein -
BTR_RS13090 561507..561656 + 150 WP_169309786.1 hypothetical protein -
BTR_RS02580 562114..562404 + 291 WP_012231079.1 hypothetical protein Antitoxin
BTR_RS02585 562401..562673 + 273 WP_012231080.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BTR_RS02590 562920..563822 + 903 Protein_479 DUF3987 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 476132..594109 117977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10612.57 Da        Isoelectric Point: 10.9313

>T22597 WP_012231080.1 NC_010161:562401-562673 [Bartonella tribocorum CIP 105476]
MKLIWTQVARVDRKKIREYISQNNPSAALKFDQLLSEKIEKLVKFSTLGRLGRVVNTREFIVHPNYIMIYDISDGVVRIL
RVLHTKQKFP

Download         Length: 273 bp

>T22597 NC_010161:562401-562673 [Bartonella tribocorum CIP 105476]
ATGAAGCTAATTTGGACACAAGTAGCACGCGTTGACCGCAAAAAGATACGTGAATACATATCACAAAATAATCCTTCTGC
TGCCTTAAAGTTTGATCAACTTTTATCTGAAAAGATAGAAAAACTCGTTAAGTTTTCTACTCTTGGTCGTTTAGGACGAG
TTGTAAATACACGTGAATTTATTGTACATCCAAATTATATCATGATTTATGATATTTCAGATGGCGTTGTTCGTATTTTA
CGTGTGCTTCATACAAAGCAAAAATTCCCTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11078.46 Da        Isoelectric Point: 5.2356

>AT22597 WP_012231079.1 NC_010161:562114-562404 [Bartonella tribocorum CIP 105476]
MAETTFTFRVDDVLKNEFSKAAKACDRSGAQLLRDYMRDIVKEQKERSAHDLWFREQVQLGINSANAGDIISSEEIEAEA
KEWRLKIQSKLDRSTL

Download         Length: 291 bp

>AT22597 NC_010161:562114-562404 [Bartonella tribocorum CIP 105476]
ATGGCTGAGACGACATTTACCTTTCGCGTTGATGATGTATTGAAAAATGAATTTTCCAAAGCAGCAAAAGCGTGTGATAG
ATCTGGTGCACAATTGTTGCGAGATTATATGCGCGATATCGTAAAAGAACAAAAAGAAAGAAGTGCACACGATTTATGGT
TTCGGGAACAGGTTCAATTAGGGATAAATTCTGCTAATGCAGGCGATATAATATCTTCTGAGGAAATCGAAGCAGAAGCA
AAGGAATGGCGCTTAAAAATACAAAGTAAACTAGATAGATCAACTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9IPY8

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9CWB1

References