Detailed information of TA system TA225969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2626725..2627311
• Replicon: chromosome
• Accession: NZ_CP087678
• Organism: Xylella taiwanensis strain PLS206

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH42_RS10925
• Protein ID: WP_038273324.1
• Coordinates: 2627057..2627311 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH42_RS10920
• Protein ID: WP_038273322.1
• Coordinates: 2626725..2627060 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH42_RS10895 (LPH42_10895)	2622153..2623361	+	1209	WP_038272829.1	hypothetical protein	-
LPH42_RS10900 (LPH42_10900)	2623863..2624183	-	321	WP_038272832.1	hypothetical protein	-
LPH42_RS10905 (LPH42_10905)	2624255..2624971	-	717	WP_160165226.1	portal protein	-
LPH42_RS10910 (LPH42_10910)	2624968..2626074	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH42_RS10915 (LPH42_10915)	2626071..2626472	-	402	WP_114867107.1	lysozyme	-
LPH42_RS10920 (LPH42_10920)	2626725..2627060	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH42_RS10925 (LPH42_10925)	2627057..2627311	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH42_RS10930 (LPH42_10930)	2627413..2628111	-	699	WP_114867108.1	hypothetical protein	-
LPH42_RS10935 (LPH42_10935)	2628068..2629261	+	1194	WP_230428203.1	hypothetical protein	-
LPH42_RS10940 (LPH42_10940)	2629265..2629537	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH42_RS10945 (LPH42_10945)	2629539..2629889	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH42_RS10950 (LPH42_10950)	2629965..2631311	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH42_RS10955 (LPH42_10955)	2631326..2632210	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2622153..2641236	19083

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T225969 WP_038273324.1 NZ_CP087678:c2627311-2627057 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T225969 NZ_CP121636:c309900-309490 [Rhizobium leguminosarum]
GTGATCACACATCTTATCGACACCAATGCGCTAATCGCCCTGATCGGCAGAAAATCCGAAATACTGCTGAAGCGCGTGAT
CGACAGCGACGAGAGATCGATCGGGCTGTCGACCGCGGTGATGCACGAGCTCTATCATGGCGCCTATAAAAGCACGAAAA
CTTCCTACAATCTCGAAACCCTGCGCCTGTTCGTGGCGGATTTCTCAGTCGTCGGCTTCGAGCAGGAGGATGCGTTGGCC
GCTGGGGAGATCCGTGCCGCATTGGCGGCAAAGGGAACGCCGATCGGCCCCTATGATGTTCTGATCGCCGCTCAGGCGAG
GACCCGGGATCTGGTTCTCGTCACCAACAATGTCGGGGTATTCCGCCGCGTCGATGGTCTGCTTGTCGAGGACTGGACGG
TCGGGCGATAG

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT225969 WP_038273322.1 NZ_CP087678:c2627060-2626725 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT225969 NZ_CP121636:c310106-309897 [Rhizobium leguminosarum]
CTGCCGAAGGAATTCCGCTTCGACGTCGACCAGGTGGAGGTGACGCGGGAGGGCGATGCTGTGATCCTTCGGCCACGGGC
CGATCGCGGCATGCGGTGGGCATCGTTGCATAGCGCCTTGGAGCGCGGCCTCAGCGACGATTTCATGGCGGAAGGGCGGG
AGCAGCCGGAGGGGCAGGACAGGCCTGATCTTCAGGACCTGTTCAAGTGA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5