Detailed information of TA system TA225964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2657609..2658195
• Replicon: chromosome
• Accession: NZ_CP087677
• Organism: Xylella taiwanensis strain PLS15A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH39_RS11060
• Protein ID: WP_038273324.1
• Coordinates: 2657941..2658195 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH39_RS11055
• Protein ID: WP_038273322.1
• Coordinates: 2657609..2657944 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH39_RS11030 (LPH39_11030)	2653037..2654245	+	1209	WP_038272829.1	hypothetical protein	-
LPH39_RS11035 (LPH39_11035)	2654747..2655067	-	321	WP_038272832.1	hypothetical protein	-
LPH39_RS11040 (LPH39_11040)	2655139..2655855	-	717	WP_160165226.1	portal protein	-
LPH39_RS11045 (LPH39_11045)	2655852..2656958	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH39_RS11050 (LPH39_11050)	2656955..2657356	-	402	WP_114867107.1	lysozyme	-
LPH39_RS11055 (LPH39_11055)	2657609..2657944	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH39_RS11060 (LPH39_11060)	2657941..2658195	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH39_RS11065 (LPH39_11065)	2658297..2658995	-	699	WP_114867108.1	hypothetical protein	-
LPH39_RS11070 (LPH39_11070)	2658952..2660145	+	1194	WP_230428203.1	hypothetical protein	-
LPH39_RS11075 (LPH39_11075)	2660149..2660421	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH39_RS11080 (LPH39_11080)	2660423..2660773	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH39_RS11085 (LPH39_11085)	2660849..2662195	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH39_RS11090 (LPH39_11090)	2662210..2663094	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2653037..2671050	18013

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T225964 WP_038273324.1 NZ_CP087677:c2658195-2657941 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T225964 NZ_CP121633:c8799-8512 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT225964 WP_038273322.1 NZ_CP087677:c2657944-2657609 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT225964 NZ_CP121633:c8525-8211 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5