Detailed information of TA system TA225959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2665076..2665662
• Replicon: chromosome
• Accession: NZ_CP087676
• Organism: Xylella taiwanensis strain PLS396

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Z9JFU4
• Locus tag: LPH43_RS11120
• Protein ID: WP_038273324.1
• Coordinates: 2665408..2665662 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Z9JGM5
• Locus tag: LPH43_RS11115
• Protein ID: WP_038273322.1
• Coordinates: 2665076..2665411 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH43_RS11090 (LPH43_11090)	2660504..2661712	+	1209	WP_038272829.1	hypothetical protein	-
LPH43_RS11095 (LPH43_11095)	2662214..2662534	-	321	WP_038272832.1	hypothetical protein	-
LPH43_RS11100 (LPH43_11100)	2662606..2663322	-	717	WP_160165226.1	portal protein	-
LPH43_RS11105 (LPH43_11105)	2663319..2664425	-	1107	WP_114867106.1	phage terminase large subunit	-
LPH43_RS11110 (LPH43_11110)	2664422..2664823	-	402	WP_114867107.1	lysozyme	-
LPH43_RS11115 (LPH43_11115)	2665076..2665411	-	336	WP_038273322.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LPH43_RS11120 (LPH43_11120)	2665408..2665662	-	255	WP_038273324.1	type II toxin-antitoxin system HicA family toxin	Toxin
LPH43_RS11125 (LPH43_11125)	2665764..2666462	-	699	WP_114867108.1	hypothetical protein	-
LPH43_RS11130 (LPH43_11130)	2666419..2667612	+	1194	WP_230428203.1	hypothetical protein	-
LPH43_RS11135 (LPH43_11135)	2667616..2667888	+	273	WP_114867070.1	VRR-NUC domain-containing protein	-
LPH43_RS11140 (LPH43_11140)	2667890..2668240	-	351	WP_114867109.1	DUF1640 domain-containing protein	-
LPH43_RS11145 (LPH43_11145)	2668316..2669662	+	1347	WP_114867110.1	DEAD/DEAH box helicase	-
LPH43_RS11150 (LPH43_11150)	2669677..2670561	+	885	WP_114867111.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2650329..2685362	35033

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-80)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.95 Da
• Isoelectric Point: 11.1842

>T225959 WP_038273324.1 NZ_CP087676:c2665662-2665408 [Xylella taiwanensis]
MKRKHAKTLSTIDTRPVSANIQWRDIEALFLELGATVEEREGSRVLVRLFGERRVFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Nucleotide

• Length: 255 bp

>T225959 NZ_CP121629:448258-448647 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12318.98 Da
• Isoelectric Point: 4.7313

>AT225959 WP_038273322.1 NZ_CP087676:c2665411-2665076 [Xylella taiwanensis]
MKNIMTIEGFKAIITYDPDIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACEEDDVEPRKSYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEIHI

Nucleotide

• Length: 336 bp

>AT225959 NZ_CP121629:447994-448251 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Toxin

• AlphaFold DB: Z9JFU4

Antitoxin

• AlphaFold DB: Z9JGM5