Detailed information of TA system TA225957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-relB/-
• Location: 1858909..1859303
• Replicon: chromosome
• Accession: NZ_CP087676
• Organism: Xylella taiwanensis strain PLS396

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: LPH43_RS07490
• Protein ID: WP_200866186.1
• Coordinates: 1858909..1859112 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Z9JJI0
• Locus tag: LPH43_RS07495
• Protein ID: WP_038270756.1
• Coordinates: 1859109..1859303 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH43_RS07470 (LPH43_07470)	1853923..1854063	+	141	WP_160165149.1	hypothetical protein	-
LPH43_RS07475 (LPH43_07475)	1854450..1855460	-	1011	WP_038270757.1	serine protease	-
LPH43_RS07480 (LPH43_07480)	1856696..1858087	+	1392	WP_051482280.1	right-handed parallel beta-helix repeat-containing protein	-
LPH43_RS07485 (LPH43_07485)	1858160..1858774	-	615	WP_230428270.1	recombinase family protein	-
LPH43_RS07490 (LPH43_07490)	1858909..1859112	-	204	WP_200866186.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LPH43_RS07495 (LPH43_07495)	1859109..1859303	-	195	WP_038270756.1	hypothetical protein	Antitoxin
LPH43_RS07500 (LPH43_07500)	1859547..1859942	+	396	WP_230428271.1	DUF4158 domain-containing protein	-
LPH43_RS07505 (LPH43_07505)	1859981..1860451	+	471	WP_230428154.1	hypothetical protein	-
LPH43_RS07510 (LPH43_07510)	1860585..1860668	+	84	Protein_1485	type II toxin-antitoxin system RelE/ParE family toxin	-
LPH43_RS07515 (LPH43_07515)	1860780..1861061	+	282	WP_038270748.1	XRE family transcriptional regulator	-
LPH43_RS07520 (LPH43_07520)	1861331..1862460	-	1130	Protein_1487	DUF5710 domain-containing protein	-
LPH43_RS07525 (LPH43_07525)	1862636..1863473	+	838	Protein_1488	VirB8/TrbF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7625.95 Da
• Isoelectric Point: 11.2308

>T225957 WP_200866186.1 NZ_CP087676:c1859112-1858909 [Xylella taiwanensis]
MTLPLHWRTSARDDLASLIRFIAYENPLTARRMKVLIEASVLLASAHPYMFRPGRVPGTREIVAHPN

Nucleotide

• Length: 204 bp

>T225957 NZ_CP121628:3404-3691 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7289.11 Da
• Isoelectric Point: 4.5007

>AT225957 WP_038270756.1 NZ_CP087676:c1859303-1859109 [Xylella taiwanensis]
MKTTPLDPIISEFATEEQAASYDRWFRAKVQASLDDSRPSVPHDQVMAEMDAIIAEAEQHRKQT

Nucleotide

• Length: 195 bp

>AT225957 NZ_CP121628:3678-3992 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Antitoxin

• AlphaFold DB: Z9JJI0