Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 46540..47081 | Replicon | chromosome |
| Accession | NZ_CP087676 | ||
| Organism | Xylella taiwanensis strain PLS396 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Z9JGT1 |
| Locus tag | LPH43_RS00305 | Protein ID | WP_038273166.1 |
| Coordinates | 46758..47081 (+) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Z9JGL9 |
| Locus tag | LPH43_RS00300 | Protein ID | WP_038273164.1 |
| Coordinates | 46540..46761 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LPH43_RS00250 (LPH43_00250) | 42116..42352 | - | 237 | WP_230428212.1 | major capsid protein | - |
| LPH43_RS00255 (LPH43_00255) | 42361..42567 | - | 207 | WP_038273075.1 | hypothetical protein | - |
| LPH43_RS00260 (LPH43_00260) | 42570..42884 | - | 315 | WP_230428211.1 | hypothetical protein | - |
| LPH43_RS00265 (LPH43_00265) | 43160..43747 | - | 588 | WP_038273076.1 | hypothetical protein | - |
| LPH43_RS00270 (LPH43_00270) | 43944..44087 | - | 144 | WP_160165233.1 | hypothetical protein | - |
| LPH43_RS00275 (LPH43_00275) | 44207..44407 | - | 201 | WP_038273077.1 | hypothetical protein | - |
| LPH43_RS00280 (LPH43_00280) | 44456..44719 | - | 264 | WP_162814095.1 | hypothetical protein | - |
| LPH43_RS00285 (LPH43_00285) | 44723..44884 | - | 162 | WP_160165236.1 | hypothetical protein | - |
| LPH43_RS00290 (LPH43_00290) | 45174..45503 | + | 330 | WP_230428286.1 | DUF3693 domain-containing protein | - |
| LPH43_RS00295 (LPH43_00295) | 45592..46092 | - | 501 | Protein_58 | tyrosine-type recombinase/integrase | - |
| LPH43_RS00300 (LPH43_00300) | 46540..46761 | + | 222 | WP_038273164.1 | antitoxin MazE family protein | Antitoxin |
| LPH43_RS00305 (LPH43_00305) | 46758..47081 | + | 324 | WP_038273166.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LPH43_RS00310 (LPH43_00310) | 47182..48330 | - | 1149 | WP_069636227.1 | zonular occludens toxin domain-containing protein | - |
| LPH43_RS00315 (LPH43_00315) | 48330..48671 | - | 342 | WP_038273089.1 | DUF2523 family protein | - |
| LPH43_RS00320 (LPH43_00320) | 48675..49742 | - | 1068 | WP_152536670.1 | virulence factor TspB C-terminal domain-related protein | - |
| LPH43_RS00325 (LPH43_00325) | 50210..50428 | - | 219 | WP_051482398.1 | major capsid protein | - |
| LPH43_RS00330 (LPH43_00330) | 50437..50646 | - | 210 | WP_230428208.1 | hypothetical protein | - |
| LPH43_RS00335 (LPH43_00335) | 50646..50939 | - | 294 | WP_038273093.1 | single-stranded DNA-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 10285..54316 | 44031 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11807.97 Da Isoelectric Point: 9.1188
>T225956 WP_038273166.1 NZ_CP087676:46758-47081 [Xylella taiwanensis]
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
MTQRGDLVTVSLQGDYGKPRPALILQSDLLMELDSVVLCPVTSELRNAIFRITVEPNIANGLRTLSQIMVDKISTLPRSK
ISKPFGHLNDERIKAVEKALLLIVGII
Download Length: 324 bp
>T225956 NZ_CP121627:34276-34635 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8490.65 Da Isoelectric Point: 8.0827
>AT225956 WP_038273164.1 NZ_CP087676:46540-46761 [Xylella taiwanensis]
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
MAFIHEPTSKVARHRKQMRAAGLRPVQFWVPDTRTPEFAAEIRSQCRSLKNDPEEADALRFTEEAITHIEGWK
Download Length: 222 bp
>AT225956 NZ_CP121627:34635-34934 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|