Detailed information of TA system TA225954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 30853..31538
• Replicon: chromosome
• Accession: NZ_CP087676
• Organism: Xylella taiwanensis strain PLS396

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LPH43_RS00150
• Protein ID: WP_038272463.1
• Coordinates: 30853..31269 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LPH43_RS00155
• Protein ID: WP_038272460.1
• Coordinates: 31266..31538 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPH43_RS00125 (LPH43_00125)	26207..27418	-	1212	WP_038272508.1	signal recognition particle-docking protein FtsY	-
LPH43_RS00130 (LPH43_00130)	28263..28736	+	474	WP_038272510.1	LEA type 2 family protein	-
LPH43_RS00135 (LPH43_00135)	29012..29626	+	615	WP_081755477.1	HNH endonuclease	-
LPH43_RS00140 (LPH43_00140)	30210..30455	+	246	WP_230428284.1	hypothetical protein	-
LPH43_RS00145 (LPH43_00145)	30446..30790	+	345	WP_038272464.1	DUF3653 domain-containing protein	-
LPH43_RS00150 (LPH43_00150)	30853..31269	-	417	WP_038272463.1	type II toxin-antitoxin system VapC family toxin	Toxin
LPH43_RS00155 (LPH43_00155)	31266..31538	-	273	WP_038272460.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LPH43_RS00160 (LPH43_00160)	31628..32755	-	1128	WP_114867127.1	zonular occludens toxin domain-containing protein	-
LPH43_RS00165 (LPH43_00165)	32768..33112	-	345	WP_038273069.1	DUF2523 family protein	-
LPH43_RS00170 (LPH43_00170)	33115..34500	-	1386	WP_230428213.1	furin-like repeat-containing protein	-
LPH43_RS00175 (LPH43_00175)	34680..34916	-	237	WP_230428212.1	major capsid protein	-
LPH43_RS00180 (LPH43_00180)	34925..35131	-	207	WP_038273075.1	hypothetical protein	-
LPH43_RS00185 (LPH43_00185)	35134..35448	-	315	WP_230428211.1	hypothetical protein	-
LPH43_RS00190 (LPH43_00190)	35724..36311	-	588	WP_038273076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	10285..54316	44031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-52)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15195.91 Da
• Isoelectric Point: 6.9048

>T225954 WP_038272463.1 NZ_CP087676:c31269-30853 [Xylella taiwanensis]
MSGYLLDTNIISDMIRNPFGLVACRIEKVDPKEVCTSIVVAAELRYGCAKKGSTKLLAKVKLMLETIPVLPLDIPTDAEY
GRIRAELESVGQTIGLNDLLIGTHAYVLGMTLVTDNVKEFKRIRGLKIENWLECASSV

Nucleotide

• Length: 417 bp

>T225954 NZ_CP121625:5269-5451 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10331.95 Da
• Isoelectric Point: 4.5216

>AT225954 WP_038272460.1 NZ_CP087676:c31538-31266 [Xylella taiwanensis]
MSISMPSSRLKEAKLFRNNRSQAVRIPVEFELPGDRVLIHREGSKLIIEPVSMPTNIIELLAQWKTEDPLGLEDQFPEIE
DMLAKPDDIF

Nucleotide

• Length: 273 bp

>AT225954 NZ_CP121625:5544-5948 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG