Detailed information of TA system TA225952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4746026..4747283
• Replicon: chromosome
• Accession: NZ_CP087675
• Organism: Pseudomonas aeruginosa strain P93127

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LO759_RS22365
• Protein ID: WP_003449003.1
• Coordinates: 4746026..4746781 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: LO759_RS22370
• Protein ID: WP_003086329.1
• Coordinates: 4746915..4747283 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO759_RS22355 (LO759_22355)	4741199..4743742	+	2544	WP_033876574.1	acyl-homoserine-lactone acylase QuiP	-
LO759_RS22360 (LO759_22360)	4743897..4745258	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
LO759_RS22365 (LO759_22365)	4746026..4746781	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
LO759_RS22370 (LO759_22370)	4746915..4747283	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
LO759_RS22375 (LO759_22375)	4747356..4748642	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
LO759_RS22380 (LO759_22380)	4748698..4750287	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
LO759_RS22385 (LO759_22385)	4750366..4750842	+	477	WP_003112531.1	hypothetical protein	-
LO759_RS22390 (LO759_22390)	4750845..4751120	-	276	WP_169057979.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T225952 WP_003449003.1 NZ_CP087675:c4746781-4746026 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T225952 NZ_CP121613:c1402-1115 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT225952 WP_003086329.1 NZ_CP087675:c4747283-4746915 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT225952 NZ_CP121613:c1128-787 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAATCATCAATAAGAATGG
GAGCTTAGGCTCCCATTTTTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7