Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3823018..3824239 Replicon chromosome
Accession NZ_CP087675
Organism Pseudomonas aeruginosa strain P93127

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LO759_RS18045 Protein ID WP_003114949.1
Coordinates 3823661..3824239 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LO759_RS18040 Protein ID WP_003088112.1
Coordinates 3823018..3823572 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO759_RS18015 (LO759_18015) 3818586..3819137 + 552 WP_003102727.1 XRE family transcriptional regulator -
LO759_RS18020 (LO759_18020) 3819134..3819532 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LO759_RS18025 (LO759_18025) 3819545..3819868 - 324 WP_034038313.1 multidrug efflux SMR transporter -
LO759_RS18030 (LO759_18030) 3820199..3820660 + 462 WP_034038312.1 (2Fe-2S)-binding protein -
LO759_RS18035 (LO759_18035) 3820665..3822860 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LO759_RS18040 (LO759_18040) 3823018..3823572 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LO759_RS18045 (LO759_18045) 3823661..3824239 + 579 WP_003114949.1 HD domain-containing protein Toxin
LO759_RS18050 (LO759_18050) 3824347..3825534 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LO759_RS18055 (LO759_18055) 3825524..3827695 - 2172 WP_042853313.1 type I secretion system permease/ATPase -
LO759_RS18060 (LO759_18060) 3827685..3828962 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T225951 WP_003114949.1 NZ_CP087675:3823661-3824239 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T225951 NZ_CP121612:c1428918-1428529 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT225951 WP_003088112.1 NZ_CP087675:3823018-3823572 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT225951 NZ_CP121612:c1429182-1428925 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References