Detailed information of TA system TA022595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 490207..490687
• Replicon: chromosome
• Accession: NC_010161
• Organism: Bartonella tribocorum CIP 105476

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A9IPB3
• Locus tag: BTR_RS02155
• Protein ID: WP_012230995.1
• Coordinates: 490418..490687 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: N6VJG4
• Locus tag: BTR_RS02150
• Protein ID: WP_007346764.1
• Coordinates: 490207..490434 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR_RS02105	485548..485754	+	207	WP_038474459.1	hypothetical protein	-
BTR_RS11915	486046..487444	+	1399	Protein_384	AAA family ATPase	-
BTR_RS02120	487593..487916	-	324	WP_038473287.1	type II toxin-antitoxin system PemK/MazF family toxin	-
BTR_RS02125	487916..488140	-	225	WP_012230987.1	antitoxin MazE family protein	-
BTR_RS02130	488363..488809	+	447	WP_012230988.1	single-stranded DNA-binding protein	-
BTR_RS02135	488863..489363	+	501	WP_012230989.1	hypothetical protein	-
BTR_RS02140	489416..489673	+	258	WP_012230990.1	antitoxin	-
BTR_RS02145	489670..489996	+	327	WP_012230991.1	type II toxin-antitoxin system PemK/MazF family toxin	-
BTR_RS02150	490207..490434	+	228	WP_007346764.1	ribbon-helix-helix protein, CopG family	Antitoxin
BTR_RS02155	490418..490687	+	270	WP_012230995.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BTR_RS02165	491236..491679	-	444	WP_012231000.1	hypothetical protein	-
BTR_RS02170	493826..494350	-	525	WP_081458153.1	hypothetical protein	-
BTR_RS02175	494485..495063	-	579	WP_012231004.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	476132..594109	117977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Protein of unknown function DUF6290 (2-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10460.48 Da
• Isoelectric Point: 10.4255

>T22595 WP_012230995.1 NC_010161:490418-490687 [Bartonella tribocorum CIP 105476]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQLSGLWRYRVGDYRILCELYDKKLVVLVLAV
GHRKNIYKG

Nucleotide

• Length: 270 bp

>T22595 NC_010161:490418-490687 [Bartonella tribocorum CIP 105476]
TTGGCTTGGACGATTAGATATGAAAAAAAAGCTCTTAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGAGGATTGT
TGATTTTTTAGATCAACACGTTGCTCCTCTTGAAGATGTGCGTGTAATAGGTAAGCCCTTAAAAGGACAATTATCAGGTT
TATGGAGATATCGTGTAGGAGATTACAGGATACTTTGTGAACTCTATGATAAGAAGCTTGTCGTATTAGTTTTGGCTGTT
GGACATAGAAAAAATATATATAAAGGTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8742.78 Da
• Isoelectric Point: 4.8780

>AT22595 WP_007346764.1 NC_010161:490207-490434 [Bartonella tribocorum CIP 105476]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Nucleotide

• Length: 228 bp

>AT22595 NC_010161:490207-490434 [Bartonella tribocorum CIP 105476]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGAATAGAGGAAGCGGAGGATTATTATTTAGCTTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Structures

Toxin

• AlphaFold DB: A9IPB3

Antitoxin

• AlphaFold DB: N6VJG4