Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 490207..490687 Replicon chromosome
Accession NC_010161
Organism Bartonella tribocorum CIP 105476

Toxin (Protein)


Gene name pasB Uniprot ID A9IPB3
Locus tag BTR_RS02155 Protein ID WP_012230995.1
Coordinates 490418..490687 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag BTR_RS02150 Protein ID WP_007346764.1
Coordinates 490207..490434 (+) Length 76 a.a.

Genomic Context

BTR_RS02105BTR_RS11915BTR_RS02130BTR_RS02135BTR_RS02140BTR_RS02145BTR_RS02150BTR_RS02155BTR_RS02120BTR_RS02125BTR_RS02165BTR_RS02170BTR_RS02175
Location: 485548..485754 (207 bp)
Type: Others
Protein ID: WP_038474459.1
Location: 486046..487444 (1399 bp)
Type: Others
Protein ID: Protein_384
Location: 488363..488809 (447 bp)
Type: Others
Protein ID: WP_012230988.1
Location: 488863..489363 (501 bp)
Type: Others
Protein ID: WP_012230989.1
Location: 489416..489673 (258 bp)
Type: Others
Protein ID: WP_012230990.1
Location: 489670..489996 (327 bp)
Type: Others
Protein ID: WP_012230991.1
Location: 490207..490434 (228 bp)
Type: Antitoxin
Protein ID: WP_007346764.1
Location: 490418..490687 (270 bp)
Type: Toxin
Protein ID: WP_012230995.1
Location: 487593..487916 (324 bp)
Type: Others
Protein ID: WP_038473287.1
Location: 487916..488140 (225 bp)
Type: Others
Protein ID: WP_012230987.1
Location: 491236..491679 (444 bp)
Type: Others
Protein ID: WP_012231000.1
Location: 493826..494350 (525 bp)
Type: Others
Protein ID: WP_081458153.1
Location: 494485..495063 (579 bp)
Type: Others
Protein ID: WP_012231004.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BTR_RS02105485548..485754+207WP_038474459.1hypothetical protein-
BTR_RS11915486046..487444+1399Protein_384AAA family ATPase-
BTR_RS02120487593..487916-324WP_038473287.1type II toxin-antitoxin system PemK/MazF family toxin-
BTR_RS02125487916..488140-225WP_012230987.1antitoxin MazE family protein-
BTR_RS02130488363..488809+447WP_012230988.1single-stranded DNA-binding protein-
BTR_RS02135488863..489363+501WP_012230989.1hypothetical protein-
BTR_RS02140489416..489673+258WP_012230990.1antitoxin-
BTR_RS02145489670..489996+327WP_012230991.1type II toxin-antitoxin system PemK/MazF family toxin-
BTR_RS02150490207..490434+228WP_007346764.1ribbon-helix-helix protein, CopG familyAntitoxin
BTR_RS02155490418..490687+270WP_012230995.1type II toxin-antitoxin system RelE/ParE family toxinToxin
BTR_RS02165491236..491679-444WP_012231000.1hypothetical protein-
BTR_RS02170493826..494350-525WP_081458153.1hypothetical protein-
BTR_RS02175494485..495063-579WP_012231004.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--476132..594109117977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10460.48 Da        Isoelectric Point: 10.4255

>T22595 WP_012230995.1 NC_010161:490418-490687 [Bartonella tribocorum CIP 105476]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQLSGLWRYRVGDYRILCELYDKKLVVLVLAV
GHRKNIYKG

Download         Length: 270 bp

>T22595 NC_010161:490418-490687 [Bartonella tribocorum CIP 105476]
TTGGCTTGGACGATTAGATATGAAAAAAAAGCTCTTAGTTTTTTAAAAAAATGCGATAAAAAAGAAGCACGGAGGATTGT
TGATTTTTTAGATCAACACGTTGCTCCTCTTGAAGATGTGCGTGTAATAGGTAAGCCCTTAAAAGGACAATTATCAGGTT
TATGGAGATATCGTGTAGGAGATTACAGGATACTTTGTGAACTCTATGATAAGAAGCTTGTCGTATTAGTTTTGGCTGTT
GGACATAGAAAAAATATATATAAAGGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT22595 WP_007346764.1 NC_010161:490207-490434 [Bartonella tribocorum CIP 105476]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT22595 NC_010161:490207-490434 [Bartonella tribocorum CIP 105476]
ATGACGATATCTATTCGGTTGCCAAGTGATCTCGAAACACGTTTGAATAATTTAGCTGCTAAGACAGGACGTACAAAGTC
TTTTTATTTACGCGAGATTATTGAACGTGGAATAGAGGAAGCGGAGGATTATTATTTAGCTTCACAAGTAAGAGAGCGCG
TTCGAAGGGGAGAGGGTACTTTTTATAGCTCTGAAGAGGTGAGGAAAGAGCTTGGCTTGGACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA9IPB3

Antitoxin

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Source
ID
Structure
AlphaFold DBN6VJG4

References