Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1604442..1605153 Replicon chromosome
Accession NZ_CP087675
Organism Pseudomonas aeruginosa strain P93127

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LO759_RS07680 Protein ID WP_033971890.1
Coordinates 1604971..1605153 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LO759_RS07675 Protein ID WP_058168140.1
Coordinates 1604442..1604924 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO759_RS07625 (LO759_07625) 1600061..1600261 + 201 WP_015649348.1 Cro/CI family transcriptional regulator -
LO759_RS07630 (LO759_07630) 1600373..1600594 + 222 WP_021205584.1 hypothetical protein -
LO759_RS07635 (LO759_07635) 1601009..1601155 + 147 Protein_1516 helix-turn-helix domain-containing protein -
LO759_RS07640 (LO759_07640) 1601396..1601728 + 333 WP_193753914.1 hypothetical protein -
LO759_RS07645 (LO759_07645) 1601725..1602408 + 684 WP_094202336.1 replication protein P -
LO759_RS07650 (LO759_07650) 1602405..1602611 + 207 WP_003159465.1 hypothetical protein -
LO759_RS07655 (LO759_07655) 1602608..1602979 + 372 WP_094202337.1 Ref family recombination enhancement nuclease -
LO759_RS07660 (LO759_07660) 1602976..1603323 + 348 WP_058168138.1 RusA family crossover junction endodeoxyribonuclease -
LO759_RS07665 (LO759_07665) 1603320..1603619 + 300 WP_033950491.1 hypothetical protein -
LO759_RS07670 (LO759_07670) 1603657..1604331 + 675 WP_021205614.1 hypothetical protein -
LO759_RS07675 (LO759_07675) 1604442..1604924 - 483 WP_058168140.1 transcriptional regulator Antitoxin
LO759_RS07680 (LO759_07680) 1604971..1605153 - 183 WP_033971890.1 type II toxin-antitoxin system HicA family toxin Toxin
LO759_RS07685 (LO759_07685) 1605353..1605685 + 333 WP_043494869.1 phage holin, lambda family -
LO759_RS07690 (LO759_07690) 1605682..1606299 + 618 WP_073665565.1 glycoside hydrolase family 19 protein -
LO759_RS07695 (LO759_07695) 1606299..1606538 + 240 WP_023114598.1 hypothetical protein -
LO759_RS07700 (LO759_07700) 1606535..1607005 + 471 WP_096861740.1 lysis system i-spanin subunit Rz -
LO759_RS07705 (LO759_07705) 1607002..1607745 + 744 WP_003159066.1 hypothetical protein -
LO759_RS07710 (LO759_07710) 1607865..1608410 + 546 WP_010791974.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1573181..1634631 61450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6776.89 Da        Isoelectric Point: 11.0775

>T225949 WP_033971890.1 NZ_CP087675:c1605153-1604971 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGTKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T225949 NZ_CP121611:c16061-15774 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 18149.69 Da        Isoelectric Point: 5.0964

>AT225949 WP_058168140.1 NZ_CP087675:c1604924-1604442 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEALENALDFLGLRLRVQIERDKDVERKMAEPPERGKLRA

Download         Length: 483 bp

>AT225949 NZ_CP121611:c15787-15473 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References