Detailed information of TA system TA225948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 164089..164594
• Replicon: chromosome
• Accession: NZ_CP087675
• Organism: Pseudomonas aeruginosa strain P93127

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LO759_RS00735
• Protein ID: WP_034037564.1
• Coordinates: 164089..164370 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: LO759_RS00740
• Protein ID: WP_003083775.1
• Coordinates: 164367..164594 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO759_RS00710 (LO759_00710)	159340..160689	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
LO759_RS00715 (LO759_00715)	160738..161424	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
LO759_RS00720 (LO759_00720)	161525..162259	+	735	WP_003117208.1	GntR family transcriptional regulator	-
LO759_RS00725 (LO759_00725)	162439..162849	+	411	WP_003101225.1	aegerolysin family protein	-
LO759_RS00730 (LO759_00730)	162881..163789	-	909	WP_016561475.1	LysR family transcriptional regulator	-
LO759_RS00735 (LO759_00735)	164089..164370	-	282	WP_034037564.1	type II toxin-antitoxin system toxin ParE	Toxin
LO759_RS00740 (LO759_00740)	164367..164594	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
LO759_RS00745 (LO759_00745)	164770..165390	-	621	WP_003101226.1	hypothetical protein	-
LO759_RS00750 (LO759_00750)	165491..165991	+	501	WP_003101228.1	LEA type 2 family protein	-
LO759_RS00755 (LO759_00755)	166064..166405	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
LO759_RS00760 (LO759_00760)	166487..167914	-	1428	WP_003083784.1	GABA permease	-
LO759_RS00765 (LO759_00765)	168083..169576	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10458.20 Da
• Isoelectric Point: 10.0435

>T225948 WP_034037564.1 NZ_CP087675:c164370-164089 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T225948 NZ_CP121611:10986-11342 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCTGATCAGCAATACGAACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT225948 WP_003083775.1 NZ_CP087675:c164594-164367 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT225948 NZ_CP121611:11335-11637 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACCATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9