Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3807804..3809025 Replicon chromosome
Accession NZ_CP087674
Organism Pseudomonas aeruginosa strain P4970C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LO758_RS17955 Protein ID WP_003114949.1
Coordinates 3808447..3809025 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LO758_RS17950 Protein ID WP_003088112.1
Coordinates 3807804..3808358 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO758_RS17925 (LO758_17925) 3803372..3803923 + 552 WP_003102727.1 XRE family transcriptional regulator -
LO758_RS17930 (LO758_17930) 3803920..3804318 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LO758_RS17935 (LO758_17935) 3804331..3804654 - 324 WP_034038313.1 multidrug efflux SMR transporter -
LO758_RS17940 (LO758_17940) 3804985..3805446 + 462 WP_034038312.1 (2Fe-2S)-binding protein -
LO758_RS17945 (LO758_17945) 3805451..3807646 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LO758_RS17950 (LO758_17950) 3807804..3808358 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LO758_RS17955 (LO758_17955) 3808447..3809025 + 579 WP_003114949.1 HD domain-containing protein Toxin
LO758_RS17960 (LO758_17960) 3809133..3810320 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LO758_RS17965 (LO758_17965) 3810310..3812481 - 2172 WP_042853313.1 type I secretion system permease/ATPase -
LO758_RS17970 (LO758_17970) 3812471..3813748 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T225945 WP_003114949.1 NZ_CP087674:3808447-3809025 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T225945 NZ_CP121609:c2632613-2632431 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT225945 WP_003088112.1 NZ_CP087674:3807804-3808358 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT225945 NZ_CP121609:c2632338-2631934 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References