Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1604436..1605147 Replicon chromosome
Accession NZ_CP087674
Organism Pseudomonas aeruginosa strain P4970C

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LO758_RS07680 Protein ID WP_033971890.1
Coordinates 1604965..1605147 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LO758_RS07675 Protein ID WP_058168140.1
Coordinates 1604436..1604918 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO758_RS07625 (LO758_07625) 1600055..1600255 + 201 WP_015649348.1 Cro/CI family transcriptional regulator -
LO758_RS07630 (LO758_07630) 1600367..1600588 + 222 WP_021205584.1 hypothetical protein -
LO758_RS07635 (LO758_07635) 1601003..1601149 + 147 Protein_1516 helix-turn-helix domain-containing protein -
LO758_RS07640 (LO758_07640) 1601390..1601722 + 333 WP_193753914.1 hypothetical protein -
LO758_RS07645 (LO758_07645) 1601719..1602402 + 684 WP_094202336.1 replication protein P -
LO758_RS07650 (LO758_07650) 1602399..1602605 + 207 WP_003159465.1 hypothetical protein -
LO758_RS07655 (LO758_07655) 1602602..1602973 + 372 WP_094202337.1 Ref family recombination enhancement nuclease -
LO758_RS07660 (LO758_07660) 1602970..1603317 + 348 WP_058168138.1 RusA family crossover junction endodeoxyribonuclease -
LO758_RS07665 (LO758_07665) 1603314..1603613 + 300 WP_033950491.1 hypothetical protein -
LO758_RS07670 (LO758_07670) 1603651..1604325 + 675 WP_021205614.1 hypothetical protein -
LO758_RS07675 (LO758_07675) 1604436..1604918 - 483 WP_058168140.1 transcriptional regulator Antitoxin
LO758_RS07680 (LO758_07680) 1604965..1605147 - 183 WP_033971890.1 type II toxin-antitoxin system HicA family toxin Toxin
LO758_RS07685 (LO758_07685) 1605347..1605679 + 333 WP_043494869.1 phage holin, lambda family -
LO758_RS07690 (LO758_07690) 1605676..1606293 + 618 WP_073665565.1 glycoside hydrolase family 19 protein -
LO758_RS07695 (LO758_07695) 1606290..1606532 + 243 WP_023875728.1 hypothetical protein -
LO758_RS07700 (LO758_07700) 1606529..1606999 + 471 WP_096861740.1 lysis system i-spanin subunit Rz -
LO758_RS07705 (LO758_07705) 1606996..1607739 + 744 WP_003159066.1 hypothetical protein -
LO758_RS07710 (LO758_07710) 1607859..1608404 + 546 WP_010791974.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1573175..1634625 61450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6776.89 Da        Isoelectric Point: 11.0775

>T225943 WP_033971890.1 NZ_CP087674:c1605147-1604965 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGTKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T225943 NZ_CP121599:26052-26411 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 18149.69 Da        Isoelectric Point: 5.0964

>AT225943 WP_058168140.1 NZ_CP087674:c1604918-1604436 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEALENALDFLGLRLRVQIERDKDVERKMAEPPERGKLRA

Download         Length: 483 bp

>AT225943 NZ_CP121599:26411-26710 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References