Detailed information of TA system TA225942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 164083..164588
• Replicon: chromosome
• Accession: NZ_CP087674
• Organism: Pseudomonas aeruginosa strain P4970C

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LO758_RS00735
• Protein ID: WP_034037564.1
• Coordinates: 164083..164364 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: LO758_RS00740
• Protein ID: WP_003083775.1
• Coordinates: 164361..164588 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO758_RS00710 (LO758_00710)	159334..160683	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
LO758_RS00715 (LO758_00715)	160732..161418	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
LO758_RS00720 (LO758_00720)	161519..162253	+	735	WP_003117208.1	GntR family transcriptional regulator	-
LO758_RS00725 (LO758_00725)	162433..162843	+	411	WP_003101225.1	aegerolysin family protein	-
LO758_RS00730 (LO758_00730)	162875..163783	-	909	WP_016561475.1	LysR family transcriptional regulator	-
LO758_RS00735 (LO758_00735)	164083..164364	-	282	WP_034037564.1	type II toxin-antitoxin system toxin ParE	Toxin
LO758_RS00740 (LO758_00740)	164361..164588	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
LO758_RS00745 (LO758_00745)	164764..165384	-	621	WP_003101226.1	hypothetical protein	-
LO758_RS00750 (LO758_00750)	165485..165985	+	501	WP_003101228.1	LEA type 2 family protein	-
LO758_RS00755 (LO758_00755)	166058..166399	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
LO758_RS00760 (LO758_00760)	166481..167908	-	1428	WP_003083784.1	GABA permease	-
LO758_RS00765 (LO758_00765)	168077..169570	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10458.20 Da
• Isoelectric Point: 10.0435

>T225942 WP_034037564.1 NZ_CP087674:c164364-164083 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T225942 NZ_CP121598:c3335751-3335362 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT225942 WP_003083775.1 NZ_CP087674:c164588-164361 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT225942 NZ_CP121598:c3336015-3335758 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C7BDS9