Detailed information of TA system TA225940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4771547..4772805
• Replicon: chromosome
• Accession: NZ_CP087673
• Organism: Pseudomonas aeruginosa strain P96131

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: LO755_RS22455
• Protein ID: WP_003086331.1
• Coordinates: 4771547..4772302 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: LO755_RS22460
• Protein ID: WP_003086329.1
• Coordinates: 4772437..4772805 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO755_RS22445 (LO755_22445)	4766718..4769261	+	2544	WP_003134033.1	acyl-homoserine-lactone acylase QuiP	-
LO755_RS22450 (LO755_22450)	4769416..4770777	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
LO755_RS22455 (LO755_22455)	4771547..4772302	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
LO755_RS22460 (LO755_22460)	4772437..4772805	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
LO755_RS22465 (LO755_22465)	4772878..4774164	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
LO755_RS22470 (LO755_22470)	4774220..4775809	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
LO755_RS22475 (LO755_22475)	4775888..4776364	+	477	WP_003086322.1	hypothetical protein	-
LO755_RS22480 (LO755_22480)	4776367..4776642	-	276	WP_023098713.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T225940 WP_003086331.1 NZ_CP087673:c4772302-4771547 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T225940 NZ_CP121597:7328-7615 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT225940 WP_003086329.1 NZ_CP087673:c4772805-4772437 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT225940 NZ_CP121597:7602-7916 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7