Detailed information of TA system TA022594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 489416..489996
• Replicon: chromosome
• Accession: NC_010161
• Organism: Bartonella tribocorum CIP 105476

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: A9IPA9
• Locus tag: BTR_RS02145
• Protein ID: WP_012230991.1
• Coordinates: 489670..489996 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: A9IPA6
• Locus tag: BTR_RS02140
• Protein ID: WP_012230990.1
• Coordinates: 489416..489673 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR_RS02105	485548..485754	+	207	WP_038474459.1	hypothetical protein	-
BTR_RS11915	486046..487444	+	1399	Protein_384	AAA family ATPase	-
BTR_RS02120	487593..487916	-	324	WP_038473287.1	type II toxin-antitoxin system PemK/MazF family toxin	-
BTR_RS02125	487916..488140	-	225	WP_012230987.1	antitoxin MazE family protein	-
BTR_RS02130	488363..488809	+	447	WP_012230988.1	single-stranded DNA-binding protein	-
BTR_RS02135	488863..489363	+	501	WP_012230989.1	hypothetical protein	-
BTR_RS02140	489416..489673	+	258	WP_012230990.1	antitoxin	Antitoxin
BTR_RS02145	489670..489996	+	327	WP_012230991.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BTR_RS02150	490207..490434	+	228	WP_007346764.1	ribbon-helix-helix protein, CopG family	-
BTR_RS02155	490418..490687	+	270	WP_012230995.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BTR_RS02165	491236..491679	-	444	WP_012231000.1	hypothetical protein	-
BTR_RS02170	493826..494350	-	525	WP_081458153.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	476132..594109	117977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12019.08 Da
• Isoelectric Point: 10.8352

>T22594 WP_012230991.1 NC_010161:489670-489996 [Bartonella tribocorum CIP 105476]
MRRGDIYMVDLEPIQGREQRGYRPVVIVSPDDFNQATGLPVILPITSGGNFVRRIGFAVPLTGTRTRGVIRCDQPRVLDL
VVRNGRKVESLPTVIMNEVLAKVVTIFS

Nucleotide

• Length: 327 bp

>T22594 NC_010161:489670-489996 [Bartonella tribocorum CIP 105476]
ATGAGGCGTGGTGATATCTATATGGTAGATTTGGAACCAATCCAAGGACGAGAGCAGCGTGGGTATCGTCCTGTCGTCAT
TGTTTCTCCTGATGATTTTAATCAAGCAACAGGTTTACCAGTTATTTTGCCGATCACAAGCGGTGGAAATTTTGTTCGCC
GTATTGGATTTGCAGTGCCGCTTACGGGTACAAGAACGAGGGGTGTTATTCGTTGCGATCAGCCTCGTGTTCTCGATTTG
GTGGTGCGCAATGGGCGTAAAGTAGAAAGTTTGCCAACAGTTATTATGAATGAAGTATTAGCGAAGGTTGTCACGATCTT
TAGTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9115.36 Da
• Isoelectric Point: 4.4610

>AT22594 WP_012230990.1 NC_010161:489416-489673 [Bartonella tribocorum CIP 105476]
MHTTKLRKVGGSVMLSIPPALLDVLHLTENSEVGLAIDNGRLVVGPSVQPRYTMAELLAASDYSQPQSPEDREWVDSSAV
GGELI

Nucleotide

• Length: 258 bp

>AT22594 NC_010161:489416-489673 [Bartonella tribocorum CIP 105476]
ATGCACACAACAAAATTACGTAAAGTTGGAGGATCAGTGATGCTCTCCATCCCACCTGCATTGCTTGATGTTCTTCACTT
GACTGAAAATAGCGAAGTTGGTTTGGCTATTGATAATGGTCGTCTTGTCGTGGGACCATCAGTCCAGCCGCGATACACGA
TGGCTGAGTTATTAGCTGCCTCCGATTATTCGCAACCACAATCACCTGAAGACCGTGAGTGGGTTGATTCCTCTGCTGTA
GGGGGCGAGCTTATATGA

Structures

Toxin

• AlphaFold DB: A9IPA9

Antitoxin

• AlphaFold DB: A9IPA6