Detailed information of TA system TA225939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3843848..3845069
• Replicon: chromosome
• Accession: NZ_CP087673
• Organism: Pseudomonas aeruginosa strain P96131

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: V6AG16
• Locus tag: LO755_RS18085
• Protein ID: WP_003088107.1
• Coordinates: 3844491..3845069 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LO755_RS18080
• Protein ID: WP_003088112.1
• Coordinates: 3843848..3844402 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO755_RS18055 (LO755_18055)	3839416..3839967	+	552	WP_023098678.1	XRE family transcriptional regulator	-
LO755_RS18060 (LO755_18060)	3839964..3840362	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
LO755_RS18065 (LO755_18065)	3840375..3840698	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
LO755_RS18070 (LO755_18070)	3841029..3841490	+	462	WP_003088117.1	(2Fe-2S)-binding protein	-
LO755_RS18075 (LO755_18075)	3841495..3843690	+	2196	WP_003088114.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
LO755_RS18080 (LO755_18080)	3843848..3844402	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
LO755_RS18085 (LO755_18085)	3844491..3845069	+	579	WP_003088107.1	HD domain-containing protein	Toxin
LO755_RS18090 (LO755_18090)	3845178..3846365	-	1188	WP_003088106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
LO755_RS18095 (LO755_18095)	3846355..3848526	-	2172	WP_003088105.1	type I secretion system permease/ATPase	-
LO755_RS18100 (LO755_18100)	3848516..3849793	-	1278	WP_003088104.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-187)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21885.74 Da
• Isoelectric Point: 5.3655

>T225939 WP_003088107.1 NZ_CP087673:3844491-3845069 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T225939 NZ_CP121596:61466-61825 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT225939 WP_003088112.1 NZ_CP087673:3843848-3844402 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT225939 NZ_CP121596:61825-62124 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Structures

Toxin

• AlphaFold DB: V6AG16