Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1875234..1876742 Replicon chromosome
Accession NZ_CP087673
Organism Pseudomonas aeruginosa strain P96131

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LO755_RS08715 Protein ID WP_073660237.1
Coordinates 1875234..1875821 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag LO755_RS08720 Protein ID WP_003091607.1
Coordinates 1875888..1876742 (+) Length 285 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO755_RS08710 (LO755_08710) 1871489..1874968 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LO755_RS08715 (LO755_08715) 1875234..1875821 + 588 WP_073660237.1 GNAT family protein Toxin
LO755_RS08720 (LO755_08720) 1875888..1876742 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
LO755_RS08725 (LO755_08725) 1876839..1879004 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
LO755_RS08730 (LO755_08730) 1879179..1881053 + 1875 WP_003091605.1 MFS transporter -
LO755_RS08735 (LO755_08735) 1881114..1881323 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-152)

Antitoxin

(19-151)


Sequences


Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T225937 WP_073660237.1 NZ_CP087673:1875234-1875821 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLVEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T225937 NZ_CP121595:c2509174-2508992 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT225937 WP_003091607.1 NZ_CP087673:1875888-1876742 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT225937 NZ_CP121595:c2508899-2508495 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References