Detailed information of TA system TA022593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 487593..488140
• Replicon: chromosome
• Accession: NC_010161
• Organism: Bartonella tribocorum CIP 105476

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: BTR_RS02120
• Protein ID: WP_038473287.1
• Coordinates: 487593..487916 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A9IP98
• Locus tag: BTR_RS02125
• Protein ID: WP_012230987.1
• Coordinates: 487916..488140 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BTR_RS02085	482778..483380	-	603	WP_012230972.1	XRE family transcriptional regulator	-
BTR_RS02090	483482..483727	+	246	WP_038474456.1	helix-turn-helix domain-containing protein	-
BTR_RS02095	483771..484249	+	479	Protein_381	hypothetical protein	-
BTR_RS02100	484239..485384	+	1146	WP_012230977.1	DUF1376 domain-containing protein	-
BTR_RS02105	485548..485754	+	207	WP_038474459.1	hypothetical protein	-
BTR_RS11915	486046..487444	+	1399	Protein_384	AAA family ATPase	-
BTR_RS02120	487593..487916	-	324	WP_038473287.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BTR_RS02125	487916..488140	-	225	WP_012230987.1	antitoxin MazE family protein	Antitoxin
BTR_RS02130	488363..488809	+	447	WP_012230988.1	single-stranded DNA-binding protein	-
BTR_RS02135	488863..489363	+	501	WP_012230989.1	hypothetical protein	-
BTR_RS02140	489416..489673	+	258	WP_012230990.1	antitoxin	-
BTR_RS02145	489670..489996	+	327	WP_012230991.1	type II toxin-antitoxin system PemK/MazF family toxin	-
BTR_RS02150	490207..490434	+	228	WP_007346764.1	ribbon-helix-helix protein, CopG family	-
BTR_RS02155	490418..490687	+	270	WP_012230995.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BTR_RS02165	491236..491679	-	444	WP_012231000.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	476132..594109	117977

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-102)

Antitoxin

• Antitoxin MazE-like (7-72)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11722.87 Da
• Isoelectric Point: 9.3693

>T22593 WP_038473287.1 NC_010161:c487916-487593 [Bartonella tribocorum CIP 105476]
MRGSLVTIAMQGDFGKPRPALIIQANQFSEHTSVTVLPITSTLVDTPLLRITLQPDSKNGLQKTSQVMIDKIMTVRCEKV
SPAFGSIHADKMVEIERCLAVFLGIVK

Nucleotide

• Length: 324 bp

>T22593 NC_010161:c487916-487593 [Bartonella tribocorum CIP 105476]
ATGCGTGGATCTCTCGTCACAATAGCTATGCAAGGCGATTTTGGTAAACCAAGACCTGCGTTAATCATTCAAGCCAATCA
ATTTAGTGAACATACAAGCGTAACGGTTTTACCCATTACCAGCACACTTGTTGATACGCCATTACTTCGCATTACTCTCC
AACCGGACAGCAAAAATGGTTTACAAAAAACTTCTCAAGTCATGATTGATAAAATTATGACGGTAAGATGTGAAAAAGTT
AGTCCAGCTTTTGGCTCCATTCATGCAGATAAAATGGTGGAAATTGAACGCTGCTTAGCTGTATTTTTGGGAATAGTAAA
ATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8790.16 Da
• Isoelectric Point: 8.5634

>AT22593 WP_012230987.1 NC_010161:c488140-487916 [Bartonella tribocorum CIP 105476]
MATMHVNERVQKHRNAQRKAGLRLMQIWVPDTRQPNFAEECRRQCRLVAKMDKTDTSMQLLMDQSLMDIDGWTE

Nucleotide

• Length: 225 bp

>AT22593 NC_010161:c488140-487916 [Bartonella tribocorum CIP 105476]
ATGGCTACAATGCACGTTAATGAACGCGTTCAAAAACATCGCAACGCACAAAGAAAAGCAGGTTTGCGCTTAATGCAAAT
TTGGGTACCAGATACTCGTCAACCAAACTTTGCAGAAGAGTGCCGACGCCAATGTCGCTTAGTCGCAAAAATGGATAAAA
CAGATACATCTATGCAGTTGTTAATGGATCAATCTTTAATGGATATTGATGGCTGGACAGAATGA

Structures

Antitoxin

• AlphaFold DB: A9IP98