Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4766561..4767077 Replicon chromosome
Accession NZ_CP087669
Organism Klebsiella pneumoniae strain KP53

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag LOM31_RS23495 Protein ID WP_004192395.1
Coordinates 4766561..4766845 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag LOM31_RS23500 Protein ID WP_004192397.1
Coordinates 4766835..4767077 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOM31_RS23470 (4761978) 4761978..4762241 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LOM31_RS23475 (4762371) 4762371..4762544 + 174 WP_002886906.1 hypothetical protein -
LOM31_RS23480 (4762547) 4762547..4763290 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LOM31_RS23485 (4763647) 4763647..4765785 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LOM31_RS23490 (4766093) 4766093..4766557 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LOM31_RS23495 (4766561) 4766561..4766845 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOM31_RS23500 (4766835) 4766835..4767077 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LOM31_RS23505 (4767155) 4767155..4769065 - 1911 WP_004152270.1 PRD domain-containing protein -
LOM31_RS23510 (4769088) 4769088..4770242 - 1155 WP_004178372.1 lactonase family protein -
LOM31_RS23515 (4770309) 4770309..4771049 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T225929 WP_004192395.1 NZ_CP087669:c4766845-4766561 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T225929 NZ_CP121584:c12278-11991 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT225929 WP_004192397.1 NZ_CP087669:c4767077-4766835 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT225929 NZ_CP121584:c12004-11690 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References