Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 4682122..4682825 | Replicon | chromosome |
| Accession | NZ_CP087669 | ||
| Organism | Klebsiella pneumoniae strain KP53 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | LOM31_RS23115 | Protein ID | WP_065803899.1 |
| Coordinates | 4682122..4682463 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A377WBK0 |
| Locus tag | LOM31_RS23120 | Protein ID | WP_053274373.1 |
| Coordinates | 4682484..4682825 (-) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOM31_RS23085 (4677144) | 4677144..4677410 | + | 267 | WP_004178415.1 | hypothetical protein | - |
| LOM31_RS23090 (4677410) | 4677410..4678082 | + | 673 | Protein_4527 | DUF4400 domain-containing protein | - |
| LOM31_RS23095 (4678093) | 4678093..4678977 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| LOM31_RS23100 (4679176) | 4679176..4679364 | - | 189 | Protein_4529 | transposase | - |
| LOM31_RS23105 (4679381) | 4679381..4680492 | - | 1112 | Protein_4530 | IS3 family transposase | - |
| LOM31_RS23110 (4680860) | 4680860..4681867 | - | 1008 | WP_004108748.1 | restriction endonuclease | - |
| LOM31_RS23115 (4682122) | 4682122..4682463 | - | 342 | WP_065803899.1 | TA system toxin CbtA family protein | Toxin |
| LOM31_RS23120 (4682484) | 4682484..4682825 | - | 342 | WP_053274373.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LOM31_RS23125 (4682836) | 4682836..4683378 | - | 543 | WP_065803898.1 | DNA repair protein RadC | - |
| LOM31_RS23130 (4683391) | 4683391..4683831 | - | 441 | WP_039567646.1 | antirestriction protein | - |
| LOM31_RS23135 (4683862) | 4683862..4684683 | - | 822 | WP_065803897.1 | DUF932 domain-containing protein | - |
| LOM31_RS23140 (4684782) | 4684782..4685003 | - | 222 | WP_065803896.1 | DUF905 domain-containing protein | - |
| LOM31_RS23145 (4685075) | 4685075..4685524 | - | 450 | WP_071571046.1 | IrmA family protein | - |
| LOM31_RS23150 (4685521) | 4685521..4685973 | - | 453 | WP_065803894.1 | hypothetical protein | - |
| LOM31_RS23155 (4686010) | 4686010..4686579 | - | 570 | WP_004929046.1 | hypothetical protein | - |
| LOM31_RS23160 (4686579) | 4686579..4687283 | - | 705 | WP_065803893.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4671255..4715196 | 43941 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12756.74 Da Isoelectric Point: 9.0089
>T225928 WP_065803899.1 NZ_CP087669:c4682463-4682122 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIHEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIHEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR
Download Length: 342 bp
>T225928 NZ_CP121584:c3547-3260 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG
Antitoxin
Download Length: 114 a.a. Molecular weight: 12773.41 Da Isoelectric Point: 6.6253
>AT225928 WP_053274373.1 NZ_CP087669:c4682825-4682484 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTQR
Download Length: 342 bp
>AT225928 NZ_CP121584:c3273-2959 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|