Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807678..808335 Replicon chromosome
Accession NZ_CP087669
Organism Klebsiella pneumoniae strain KP53

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LOM31_RS04005 Protein ID WP_002916310.1
Coordinates 807925..808335 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LOM31_RS04000 Protein ID WP_002916312.1
Coordinates 807678..807944 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOM31_RS03975 (802834) 802834..804267 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LOM31_RS03980 (804386) 804386..805114 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LOM31_RS03985 (805164) 805164..805475 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LOM31_RS03990 (805639) 805639..806298 + 660 WP_002916317.1 hemolysin III family protein -
LOM31_RS03995 (806449) 806449..807432 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LOM31_RS04000 (807678) 807678..807944 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LOM31_RS04005 (807925) 807925..808335 + 411 WP_002916310.1 protein YgfX Toxin
LOM31_RS04010 (808342) 808342..808863 - 522 WP_002916308.1 flavodoxin FldB -
LOM31_RS04015 (808964) 808964..809860 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LOM31_RS04020 (809883) 809883..810596 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LOM31_RS04025 (810602) 810602..812335 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T225914 WP_002916310.1 NZ_CP087669:807925-808335 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T225914 NZ_CP121563:c3301626-3301444 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225914 WP_002916312.1 NZ_CP087669:807678-807944 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225914 NZ_CP121563:c3301351-3300947 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References