Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 105043..105953 | Replicon | plasmid pDD01845-1 |
| Accession | NZ_CP087664 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD01845 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | LMH56_RS27290 | Protein ID | WP_004026354.1 |
| Coordinates | 105043..105513 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | LMH56_RS27295 | Protein ID | WP_004026357.1 |
| Coordinates | 105510..105953 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH56_RS27265 (LMH56_27265) | 100455..100853 | - | 399 | WP_004212796.1 | H-NS family nucleoid-associated regulatory protein | - |
| LMH56_RS27270 (LMH56_27270) | 101190..101684 | - | 495 | WP_004212794.1 | thermonuclease family protein | - |
| LMH56_RS27275 (LMH56_27275) | 101862..102128 | + | 267 | WP_223175074.1 | DUF1173 family protein | - |
| LMH56_RS27280 (LMH56_27280) | 102161..102811 | + | 651 | WP_068893702.1 | DUF1173 family protein | - |
| LMH56_RS27290 (LMH56_27290) | 105043..105513 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| LMH56_RS27295 (LMH56_27295) | 105510..105953 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| LMH56_RS27300 (LMH56_27300) | 106054..106557 | - | 504 | Protein_112 | DUF4113 domain-containing protein | - |
| LMH56_RS27305 (LMH56_27305) | 106763..107743 | - | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
| LMH56_RS27310 (LMH56_27310) | 107809..109116 | + | 1308 | Protein_114 | FepA family TonB-dependent siderophore receptor | - |
| LMH56_RS27315 (LMH56_27315) | 109178..109399 | + | 222 | WP_004213615.1 | hypothetical protein | - |
| LMH56_RS27320 (LMH56_27320) | 109542..110444 | - | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
| LMH56_RS27325 (LMH56_27325) | 110517..110918 | - | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..219069 | 219069 | |
| - | inside | IScluster/Tn | - | - | 99004..107743 | 8739 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T225903 WP_004026354.1 NZ_CP087664:c105513-105043 [Klebsiella pneumoniae subsp. pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T225903 NZ_CP121529:990370-990579 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT225903 WP_004026357.1 NZ_CP087664:c105953-105510 [Klebsiella pneumoniae subsp. pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT225903 NZ_CP121529:990070-990363 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |