Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5358070..5358695 Replicon chromosome
Accession NZ_CP087663
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01845

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LMH56_RS26385 Protein ID WP_002882817.1
Coordinates 5358070..5358453 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LMH56_RS26390 Protein ID WP_004150355.1
Coordinates 5358453..5358695 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH56_RS26370 (LMH56_26370) 5355436..5356338 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LMH56_RS26375 (LMH56_26375) 5356335..5356970 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LMH56_RS26380 (LMH56_26380) 5356967..5357896 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LMH56_RS26385 (LMH56_26385) 5358070..5358453 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LMH56_RS26390 (LMH56_26390) 5358453..5358695 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LMH56_RS26395 (LMH56_26395) 5358900..5359817 + 918 WP_004181612.1 alpha/beta hydrolase -
LMH56_RS26400 (LMH56_26400) 5359831..5360772 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LMH56_RS26405 (LMH56_26405) 5360817..5361254 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LMH56_RS26410 (LMH56_26410) 5361251..5362111 - 861 WP_004146232.1 virulence factor BrkB family protein -
LMH56_RS26415 (LMH56_26415) 5362105..5362704 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T225901 WP_002882817.1 NZ_CP087663:c5358453-5358070 [Klebsiella pneumoniae subsp. pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T225901 NZ_CP121527:249941-250120 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAATGCTATGGTTACCGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTAAAAAAACAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT225901 WP_004150355.1 NZ_CP087663:c5358695-5358453 [Klebsiella pneumoniae subsp. pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT225901 NZ_CP121527:249318-249917 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGATAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAATTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTAG
AAAATCATACAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGTAACCTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References