Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4881728..4882244 Replicon chromosome
Accession NZ_CP087663
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01845

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LMH56_RS24110 Protein ID WP_002886902.1
Coordinates 4881728..4882012 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LMH56_RS24115 Protein ID WP_002886901.1
Coordinates 4882002..4882244 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH56_RS24085 (LMH56_24085) 4877212..4877475 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LMH56_RS24090 (LMH56_24090) 4877605..4877778 + 174 WP_002886906.1 hypothetical protein -
LMH56_RS24095 (LMH56_24095) 4877781..4878524 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LMH56_RS24100 (LMH56_24100) 4878881..4881019 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LMH56_RS24105 (LMH56_24105) 4881260..4881724 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LMH56_RS24110 (LMH56_24110) 4881728..4882012 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMH56_RS24115 (LMH56_24115) 4882002..4882244 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LMH56_RS24120 (LMH56_24120) 4882322..4884232 - 1911 WP_004152270.1 PRD domain-containing protein -
LMH56_RS24125 (LMH56_24125) 4884255..4885409 - 1155 WP_002886900.1 lactonase family protein -
LMH56_RS24130 (LMH56_24130) 4885475..4886215 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T225899 WP_002886902.1 NZ_CP087663:c4882012-4881728 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T225899 NZ_CP121527:69555-69764 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT225899 WP_002886901.1 NZ_CP087663:c4882244-4882002 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT225899 NZ_CP121527:69255-69548 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References