Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878322..878976 Replicon chromosome
Accession NZ_CP087663
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01845

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LMH56_RS04395 Protein ID WP_004144731.1
Coordinates 878569..878976 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LMH56_RS04390 Protein ID WP_002916312.1
Coordinates 878322..878588 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH56_RS04365 (LMH56_04365) 873478..874911 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LMH56_RS04370 (LMH56_04370) 875030..875758 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LMH56_RS04375 (LMH56_04375) 875808..876119 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LMH56_RS04380 (LMH56_04380) 876283..876942 + 660 WP_002916317.1 hemolysin III family protein -
LMH56_RS04385 (LMH56_04385) 877093..878076 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LMH56_RS04390 (LMH56_04390) 878322..878588 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LMH56_RS04395 (LMH56_04395) 878569..878976 + 408 WP_004144731.1 protein YgfX Toxin
LMH56_RS04400 (LMH56_04400) 878983..879504 - 522 WP_002916308.1 flavodoxin FldB -
LMH56_RS04405 (LMH56_04405) 879605..880501 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LMH56_RS04410 (LMH56_04410) 880524..881237 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMH56_RS04415 (LMH56_04415) 881243..882976 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T225887 WP_004144731.1 NZ_CP087663:878569-878976 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T225887 NZ_CP121518:c12257-11895 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225887 WP_002916312.1 NZ_CP087663:878322-878588 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225887 NZ_CP121518:c12424-12254 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References