Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 105043..105953 Replicon plasmid pDD01635-1
Accession NZ_CP087658
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01635

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag LMH51_RS27765 Protein ID WP_004026354.1
Coordinates 105043..105513 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag LMH51_RS27770 Protein ID WP_004026357.1
Coordinates 105510..105953 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH51_RS27740 (LMH51_27740) 100455..100853 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
LMH51_RS27745 (LMH51_27745) 101190..101684 - 495 WP_004212794.1 thermonuclease family protein -
LMH51_RS27750 (LMH51_27750) 101862..102128 + 267 WP_223175074.1 DUF1173 family protein -
LMH51_RS27755 (LMH51_27755) 102161..102811 + 651 WP_068893702.1 DUF1173 family protein -
LMH51_RS27765 (LMH51_27765) 105043..105513 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
LMH51_RS27770 (LMH51_27770) 105510..105953 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
LMH51_RS27775 (LMH51_27775) 106054..106557 - 504 Protein_112 DUF4113 domain-containing protein -
LMH51_RS27780 (LMH51_27780) 106763..107743 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
LMH51_RS27785 (LMH51_27785) 107809..109116 + 1308 Protein_114 FepA family TonB-dependent siderophore receptor -
LMH51_RS27790 (LMH51_27790) 109178..109399 + 222 WP_004213615.1 hypothetical protein -
LMH51_RS27795 (LMH51_27795) 109542..110444 - 903 WP_004213613.1 DMT family inner membrane transporter PEG344 -
LMH51_RS27800 (LMH51_27800) 110517..110918 - 402 WP_214588034.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / rmpA / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..219068 219068
- inside IScluster/Tn - - 99004..107743 8739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T225878 WP_004026354.1 NZ_CP087658:c105513-105043 [Klebsiella pneumoniae subsp. pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T225878 NZ_CP121507:2202587-2202775 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT225878 WP_004026357.1 NZ_CP087658:c105953-105510 [Klebsiella pneumoniae subsp. pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT225878 NZ_CP121507:2202305-2202562 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAATTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CCCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References