Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4953693..4954209 Replicon chromosome
Accession NZ_CP087657
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01635

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LMH51_RS24585 Protein ID WP_002886902.1
Coordinates 4953693..4953977 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LMH51_RS24590 Protein ID WP_002886901.1
Coordinates 4953967..4954209 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH51_RS24560 (LMH51_24560) 4949177..4949440 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LMH51_RS24565 (LMH51_24565) 4949570..4949743 + 174 WP_002886906.1 hypothetical protein -
LMH51_RS24570 (LMH51_24570) 4949746..4950489 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LMH51_RS24575 (LMH51_24575) 4950846..4952984 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LMH51_RS24580 (LMH51_24580) 4953225..4953689 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LMH51_RS24585 (LMH51_24585) 4953693..4953977 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMH51_RS24590 (LMH51_24590) 4953967..4954209 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LMH51_RS24595 (LMH51_24595) 4954287..4956197 - 1911 WP_004152270.1 PRD domain-containing protein -
LMH51_RS24600 (LMH51_24600) 4956220..4957374 - 1155 WP_002886900.1 lactonase family protein -
LMH51_RS24605 (LMH51_24605) 4957440..4958180 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T225874 WP_002886902.1 NZ_CP087657:c4953977-4953693 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T225874 NZ_CP121502:c1440564-1440355 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT225874 WP_002886901.1 NZ_CP087657:c4954209-4953967 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT225874 NZ_CP121502:c1440864-1440571 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References