Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3205496..3206116 Replicon chromosome
Accession NC_010159
Organism Yersinia pestis Angola

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YPANGOLA_RS16020 Protein ID WP_002208622.1
Coordinates 3205913..3206116 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag YPANGOLA_RS16015 Protein ID WP_002218472.1
Coordinates 3205496..3205864 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPANGOLA_RS15985 3202115..3202777 + 663 WP_002228565.1 hypothetical protein -
YPANGOLA_RS15995 3202995..3203453 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
YPANGOLA_RS16000 3203691..3203951 + 261 Protein_2835 type B 50S ribosomal protein L31 -
YPANGOLA_RS16005 3203967..3204110 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YPANGOLA_RS16010 3204984..3205337 + 354 WP_002208619.1 hypothetical protein -
YPANGOLA_RS16015 3205496..3205864 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
YPANGOLA_RS16020 3205913..3206116 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
YPANGOLA_RS16025 3207004..3207393 + 390 WP_002208623.1 MGMT family protein -
YPANGOLA_RS16030 3207503..3207991 - 489 Protein_2841 YbaY family lipoprotein -
YPANGOLA_RS16035 3208248..3209108 + 861 WP_002208625.1 acyl-CoA thioesterase II -
YPANGOLA_RS16040 3209368..3210657 - 1290 WP_002228344.1 ammonium transporter AmtB -
YPANGOLA_RS16045 3210697..3211035 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3202995..3203453 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T22587 WP_002208622.1 NC_010159:3205913-3206116 [Yersinia pestis Angola]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T22587 NC_010159:3205913-3206116 [Yersinia pestis Angola]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT22587 WP_002218472.1 NC_010159:3205496-3205864 [Yersinia pestis Angola]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT22587 NC_010159:3205496-3205864 [Yersinia pestis Angola]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACACTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References