Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 879771..880425 Replicon chromosome
Accession NZ_CP087657
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01635

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LMH51_RS04405 Protein ID WP_004144731.1
Coordinates 880018..880425 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LMH51_RS04400 Protein ID WP_002916312.1
Coordinates 879771..880037 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH51_RS04375 (LMH51_04375) 874927..876360 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LMH51_RS04380 (LMH51_04380) 876479..877207 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LMH51_RS04385 (LMH51_04385) 877257..877568 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LMH51_RS04390 (LMH51_04390) 877732..878391 + 660 WP_002916317.1 hemolysin III family protein -
LMH51_RS04395 (LMH51_04395) 878542..879525 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LMH51_RS04400 (LMH51_04400) 879771..880037 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LMH51_RS04405 (LMH51_04405) 880018..880425 + 408 WP_004144731.1 protein YgfX Toxin
LMH51_RS04410 (LMH51_04410) 880432..880953 - 522 WP_002916308.1 flavodoxin FldB -
LMH51_RS04415 (LMH51_04415) 881054..881950 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LMH51_RS04420 (LMH51_04420) 881973..882686 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMH51_RS04425 (LMH51_04425) 882692..884425 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T225862 WP_004144731.1 NZ_CP087657:880018-880425 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T225862 NZ_CP121483:2494488-2494850 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225862 WP_002916312.1 NZ_CP087657:879771-880037 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225862 NZ_CP121483:2494321-2494491 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References