Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 344854..345440 Replicon chromosome
Accession NZ_CP087657
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01635

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag LMH51_RS01610 Protein ID WP_002920800.1
Coordinates 345072..345440 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LMH51_RS01605 Protein ID WP_004174006.1
Coordinates 344854..345075 (+) Length 74 a.a.

Genomic Context


LMH51_RS01585LMH51_RS01590LMH51_RS01595LMH51_RS01600LMH51_RS01605LMH51_RS01610LMH51_RS01615LMH51_RS01620LMH51_RS01625LMH51_RS01630
Location: 341011..341937 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 341934..343211 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Location: 343208..343975 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 343977..344690 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 344854..345075 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 345072..345440 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 345713..347029 (1317 bp)
Type: Others
Protein ID: WP_004174008.1
Location: 347136..348023 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 348020..348865 (846 bp)
Type: Others
Protein ID: WP_004181473.1
Location: 348867..349937 (1071 bp)
Type: Others
Protein ID: WP_004150074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LMH51_RS01585 (LMH51_01585)341011..341937+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
LMH51_RS01590 (LMH51_01590)341934..343211+1278WP_004174005.1branched chain amino acid ABC transporter permease LivM-
LMH51_RS01595 (LMH51_01595)343208..343975+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
LMH51_RS01600 (LMH51_01600)343977..344690+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
LMH51_RS01605 (LMH51_01605)344854..345075+222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
LMH51_RS01610 (LMH51_01610)345072..345440+369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
LMH51_RS01615 (LMH51_01615)345713..347029+1317WP_004174008.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
LMH51_RS01620 (LMH51_01620)347136..348023+888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
LMH51_RS01625 (LMH51_01625)348020..348865+846WP_004181473.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
LMH51_RS01630 (LMH51_01630)348867..349937+1071WP_004150074.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--305217..35067445457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-50)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T225860 WP_002920800.1 NZ_CP087657:345072-345440 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T225860 NZ_CP121483:1142766-1142954 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT225860 WP_004174006.1 NZ_CP087657:344854-345075 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT225860 NZ_CP121483:1142484-1142741 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAACTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GUD1


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References