Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 344854..345440 | Replicon | chromosome |
Accession | NZ_CP087657 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD01635 |
Toxin (Protein)
Gene name | doc | Uniprot ID | W8VD46 |
Locus tag | LMH51_RS01610 | Protein ID | WP_002920800.1 |
Coordinates | 345072..345440 (+) | Length | 123 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | W9B1V1 |
Locus tag | LMH51_RS01605 | Protein ID | WP_004174006.1 |
Coordinates | 344854..345075 (+) | Length | 74 a.a. |
Genomic Context
Location: 341011..341937 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Type: Others
Protein ID: WP_002920807.1
Location: 341934..343211 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Type: Others
Protein ID: WP_004174005.1
Location: 343208..343975 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Type: Others
Protein ID: WP_002920803.1
Location: 343977..344690 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Type: Others
Protein ID: WP_004145133.1
Location: 344854..345075 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 345072..345440 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Type: Toxin
Protein ID: WP_002920800.1
Location: 345713..347029 (1317 bp)
Type: Others
Protein ID: WP_004174008.1
Type: Others
Protein ID: WP_004174008.1
Location: 347136..348023 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Type: Others
Protein ID: WP_002920792.1
Location: 348020..348865 (846 bp)
Type: Others
Protein ID: WP_004181473.1
Type: Others
Protein ID: WP_004181473.1
Location: 348867..349937 (1071 bp)
Type: Others
Protein ID: WP_004150074.1
Type: Others
Protein ID: WP_004150074.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LMH51_RS01585 (LMH51_01585) | 341011..341937 | + | 927 | WP_002920807.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
LMH51_RS01590 (LMH51_01590) | 341934..343211 | + | 1278 | WP_004174005.1 | branched chain amino acid ABC transporter permease LivM | - |
LMH51_RS01595 (LMH51_01595) | 343208..343975 | + | 768 | WP_002920803.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
LMH51_RS01600 (LMH51_01600) | 343977..344690 | + | 714 | WP_004145133.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
LMH51_RS01605 (LMH51_01605) | 344854..345075 | + | 222 | WP_004174006.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
LMH51_RS01610 (LMH51_01610) | 345072..345440 | + | 369 | WP_002920800.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
LMH51_RS01615 (LMH51_01615) | 345713..347029 | + | 1317 | WP_004174008.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
LMH51_RS01620 (LMH51_01620) | 347136..348023 | + | 888 | WP_002920792.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
LMH51_RS01625 (LMH51_01625) | 348020..348865 | + | 846 | WP_004181473.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
LMH51_RS01630 (LMH51_01630) | 348867..349937 | + | 1071 | WP_004150074.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 305217..350674 | 45457 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13552.92 Da Isoelectric Point: 8.6410
>T225860 WP_002920800.1 NZ_CP087657:345072-345440 [Klebsiella pneumoniae subsp. pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
Download Length: 369 bp
>T225860 NZ_CP121483:1142766-1142954 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAAAGAAGAACGAAAAGAATCTTATCTAGGCTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTCGGAATTTTATAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8151.15 Da Isoelectric Point: 4.7769
>AT225860 WP_004174006.1 NZ_CP087657:344854-345075 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
Download Length: 222 bp
>AT225860 NZ_CP121483:1142484-1142741 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATATATTCAACTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA
ATGAAATTAAACAAAGCAAATATATTCAACTTGATATTCACCATTTTATTTTTTTCATTTAACATTCTCATAACCTATAA
CGCAAATATAGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGTTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTGTATTACATTTATCCGATT
TTTTATGAATTTGTCTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GUD1 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5E5YJY7 |