Detailed information of TA system TA022586

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2650029..2651012
• Replicon: chromosome
• Accession: NC_010159
• Organism: Yersinia pestis Angola

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: YPANGOLA_RS13480
• Protein ID: WP_002210981.1
• Coordinates: 2650554..2651012 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: YPANGOLA_RS13475
• Protein ID: WP_012229742.1
• Coordinates: 2650029..2650475 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPANGOLA_RS13455	2645460..2646242	-	783	WP_001317493.1	IS21-like element IS100kyp family helper ATPase IstB	-
YPANGOLA_RS13460	2646239..2647261	-	1023	WP_000255944.1	IS21-like element IS100 family transposase	-
YPANGOLA_RS13465	2647511..2647969	+	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
YPANGOLA_RS13470	2648116..2649693	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
YPANGOLA_RS13475	2650029..2650475	+	447	WP_012229742.1	DUF2384 domain-containing protein	Antitoxin
YPANGOLA_RS13480	2650554..2651012	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
YPANGOLA_RS13485	2651022..2652083	-	1062	WP_002210980.1	YcjF family protein	-
YPANGOLA_RS13490	2652080..2653477	-	1398	WP_002210979.1	YcjX family protein	-
YPANGOLA_RS13495	2653458..2653700	-	243	WP_002216375.1	phage shock protein PspD	-
YPANGOLA_RS13500	2653785..2654144	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
YPANGOLA_RS13505	2654144..2654371	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
YPANGOLA_RS13510	2654533..2655198	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T22586 WP_002210981.1 NC_010159:2650554-2651012 [Yersinia pestis Angola]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T22586 NC_010159:2650554-2651012 [Yersinia pestis Angola]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16389.89 Da
• Isoelectric Point: 9.7155

>AT22586 WP_012229742.1 NC_010159:2650029-2650475 [Yersinia pestis Angola]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKATTWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT22586 NC_010159:2650029-2650475 [Yersinia pestis Angola]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAC
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6