Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2737001..2738589 | Replicon | chromosome |
| Accession | NZ_CP087651 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD01653 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0H3GN97 |
| Locus tag | LL272_RS13505 | Protein ID | WP_004199851.1 |
| Coordinates | 2737001..2738323 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | LL272_RS13510 | Protein ID | WP_002904790.1 |
| Coordinates | 2738323..2738589 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LL272_RS13490 (LL272_13490) | 2732066..2734567 | + | 2502 | WP_004199853.1 | fimbria/pilus outer membrane usher protein | - |
| LL272_RS13495 (LL272_13495) | 2734555..2735559 | + | 1005 | WP_004199852.1 | fimbrial protein | - |
| LL272_RS13500 (LL272_13500) | 2735692..2736984 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| LL272_RS13505 (LL272_13505) | 2737001..2738323 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LL272_RS13510 (LL272_13510) | 2738323..2738589 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| LL272_RS13515 (LL272_13515) | 2738855..2739181 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| LL272_RS13520 (LL272_13520) | 2739178..2739678 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| LL272_RS13525 (LL272_13525) | 2739656..2741035 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
| LL272_RS13530 (LL272_13530) | 2741381..2742535 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| LL272_RS13535 (LL272_13535) | 2742516..2743439 | - | 924 | WP_004199849.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T225844 WP_004199851.1 NZ_CP087651:c2738323-2737001 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T225844 NZ_CP121464:c1523090-1522794 [Janthinobacterium rivuli]
ATGATACAAAAACTCAACAAGTGGGATAGCGCGCAGCACCTCAAAACCGAAGAGGATATCGTCGCCTACTTTGAAGCTTG
CCTGGAAGAAGCGGGCGACGACGCATCCTTCATCGCCAAAGCGCTCGGCAACATTGCCAAGGCGCGCGGCATGACGCAAC
TTGCCAAGGATACCGGATTGGGACGGGAAAGTTTGTACAAGGCCTTGTCCGGCGAAGGCAATCCAAGCTTCGACACCATT
TTGAAGGTGACGCATGCACTCGGCTTGCAATTTCGCGCCGCAGCGCTGAACACCTGA
ATGATACAAAAACTCAACAAGTGGGATAGCGCGCAGCACCTCAAAACCGAAGAGGATATCGTCGCCTACTTTGAAGCTTG
CCTGGAAGAAGCGGGCGACGACGCATCCTTCATCGCCAAAGCGCTCGGCAACATTGCCAAGGCGCGCGGCATGACGCAAC
TTGCCAAGGATACCGGATTGGGACGGGAAAGTTTGTACAAGGCCTTGTCCGGCGAAGGCAATCCAAGCTTCGACACCATT
TTGAAGGTGACGCATGCACTCGGCTTGCAATTTCGCGCCGCAGCGCTGAACACCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT225844 WP_002904790.1 NZ_CP087651:c2738589-2738323 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT225844 NZ_CP121464:c1523389-1523090 [Janthinobacterium rivuli]
GTGAAAAGCATCCATACCACCGCCACGTTCGATGACTGGTTCAGCCAGTTGAAGGATCGGAAAGCTTTTTTCCGCATCCA
GGCCCGTATTGACCGTGCCGAAGACGGCAACTTTGGCGATTGCAAACCTGTCGGTGGCGGCGTTTCGGAAATGCGAATTG
ATTGTGGTCCCGGTTACCGCGTTTATTTCACCCAGCGCGGCATGGAAATAATCATCCTGCTCGCTGGCGGCGACAAATCA
ACGCAAGCAAAAGATATCAAAACGGCGCAGCGGCTCGCGCAAATACTCCAGGAGGTCTGA
GTGAAAAGCATCCATACCACCGCCACGTTCGATGACTGGTTCAGCCAGTTGAAGGATCGGAAAGCTTTTTTCCGCATCCA
GGCCCGTATTGACCGTGCCGAAGACGGCAACTTTGGCGATTGCAAACCTGTCGGTGGCGGCGTTTCGGAAATGCGAATTG
ATTGTGGTCCCGGTTACCGCGTTTATTTCACCCAGCGCGGCATGGAAATAATCATCCTGCTCGCTGGCGGCGACAAATCA
ACGCAAGCAAAAGATATCAAAACGGCGCAGCGGCTCGCGCAAATACTCCAGGAGGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GN97 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |