Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2793499..2795087 | Replicon | chromosome |
| Accession | NZ_CP087645 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD01754 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0H3GN97 |
| Locus tag | LMH55_RS13915 | Protein ID | WP_004199851.1 |
| Coordinates | 2793499..2794821 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | LMH55_RS13920 | Protein ID | WP_002904790.1 |
| Coordinates | 2794821..2795087 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH55_RS13900 (LMH55_13900) | 2788564..2791065 | + | 2502 | WP_004199853.1 | fimbria/pilus outer membrane usher protein | - |
| LMH55_RS13905 (LMH55_13905) | 2791053..2792057 | + | 1005 | WP_004199852.1 | fimbrial protein | - |
| LMH55_RS13910 (LMH55_13910) | 2792190..2793482 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| LMH55_RS13915 (LMH55_13915) | 2793499..2794821 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LMH55_RS13920 (LMH55_13920) | 2794821..2795087 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| LMH55_RS13925 (LMH55_13925) | 2795353..2795679 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| LMH55_RS13930 (LMH55_13930) | 2795676..2796176 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| LMH55_RS13935 (LMH55_13935) | 2796154..2797533 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
| LMH55_RS13940 (LMH55_13940) | 2797879..2799033 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| LMH55_RS13945 (LMH55_13945) | 2799014..2799937 | - | 924 | WP_004199849.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T225819 WP_004199851.1 NZ_CP087645:c2794821-2793499 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T225819 NZ_CP121370:c110599-110336 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT225819 WP_002904790.1 NZ_CP087645:c2795087-2794821 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT225819 NZ_CP121370:c110849-110586 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GN97 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |