Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880439..881093 Replicon chromosome
Accession NZ_CP087645
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01754

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LMH55_RS04445 Protein ID WP_004144731.1
Coordinates 880686..881093 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LMH55_RS04440 Protein ID WP_002916312.1
Coordinates 880439..880705 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH55_RS04415 (LMH55_04415) 875595..877028 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LMH55_RS04420 (LMH55_04420) 877147..877875 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LMH55_RS04425 (LMH55_04425) 877925..878236 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LMH55_RS04430 (LMH55_04430) 878400..879059 + 660 WP_002916317.1 hemolysin III family protein -
LMH55_RS04435 (LMH55_04435) 879210..880193 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LMH55_RS04440 (LMH55_04440) 880439..880705 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LMH55_RS04445 (LMH55_04445) 880686..881093 + 408 WP_004144731.1 protein YgfX Toxin
LMH55_RS04450 (LMH55_04450) 881100..881621 - 522 WP_002916308.1 flavodoxin FldB -
LMH55_RS04455 (LMH55_04455) 881722..882618 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LMH55_RS04460 (LMH55_04460) 882641..883354 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMH55_RS04465 (LMH55_04465) 883360..885093 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T225810 WP_004144731.1 NZ_CP087645:880686-881093 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T225810 NZ_CP121365:c110867-110604 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225810 WP_002916312.1 NZ_CP087645:880439-880705 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225810 NZ_CP121365:c110617-110354 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References