Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 84092..85002 | Replicon | plasmid pDD02391-2 |
| Accession | NZ_CP087641 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02391 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | LMH57_RS28390 | Protein ID | WP_004026354.1 |
| Coordinates | 84092..84562 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | LMH57_RS28395 | Protein ID | WP_004026357.1 |
| Coordinates | 84559..85002 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH57_RS28350 (LMH57_28350) | 79408..79722 | + | 315 | WP_011251273.1 | hypothetical protein | - |
| LMH57_RS28355 (LMH57_28355) | 79731..80225 | + | 495 | WP_011251274.1 | hypothetical protein | - |
| LMH57_RS28360 (LMH57_28360) | 80231..80671 | + | 441 | WP_011251275.1 | hypothetical protein | - |
| LMH57_RS28365 (LMH57_28365) | 81096..82052 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| LMH57_RS28370 (LMH57_28370) | 82112..82453 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| LMH57_RS28375 (LMH57_28375) | 82467..82778 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| LMH57_RS28380 (LMH57_28380) | 82795..83244 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| LMH57_RS28390 (LMH57_28390) | 84092..84562 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| LMH57_RS28395 (LMH57_28395) | 84559..85002 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| LMH57_RS28400 (LMH57_28400) | 85103..85606 | - | 504 | Protein_97 | DUF4113 domain-containing protein | - |
| LMH57_RS28405 (LMH57_28405) | 85812..86792 | - | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
| LMH57_RS28410 (LMH57_28410) | 87219..87851 | + | 633 | WP_004213609.1 | mucoid phenotype regulator RmpA | - |
| LMH57_RS28415 (LMH57_28415) | 87907..88029 | + | 123 | WP_213034833.1 | mucoid phenotype synthesis protein RmpD | - |
| LMH57_RS28420 (LMH57_28420) | 88382..88783 | + | 402 | WP_214588034.1 | LuxR C-terminal-related transcriptional regulator | - |
| LMH57_RS28425 (LMH57_28425) | 88856..89758 | + | 903 | WP_004213613.1 | DMT family inner membrane transporter PEG344 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | rmpA / iroN | 1..132733 | 132733 | |
| - | inside | IScluster/Tn | - | rmpA / iroN | 77811..97788 | 19977 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T225805 WP_004026354.1 NZ_CP087641:c84562-84092 [Klebsiella pneumoniae subsp. pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T225805 NZ_CP121360:c30733-30455 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT225805 WP_004026357.1 NZ_CP087641:c85002-84559 [Klebsiella pneumoniae subsp. pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT225805 NZ_CP121360:c31002-30733 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCTGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGATAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCTGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |