Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878887..879541 Replicon chromosome
Accession NZ_CP087639
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02391

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LMH57_RS04435 Protein ID WP_004144731.1
Coordinates 879134..879541 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LMH57_RS04430 Protein ID WP_002916312.1
Coordinates 878887..879153 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH57_RS04405 (LMH57_04405) 874043..875476 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LMH57_RS04410 (LMH57_04410) 875595..876323 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LMH57_RS04415 (LMH57_04415) 876373..876684 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LMH57_RS04420 (LMH57_04420) 876848..877507 + 660 WP_002916317.1 hemolysin III family protein -
LMH57_RS04425 (LMH57_04425) 877658..878641 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LMH57_RS04430 (LMH57_04430) 878887..879153 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LMH57_RS04435 (LMH57_04435) 879134..879541 + 408 WP_004144731.1 protein YgfX Toxin
LMH57_RS04440 (LMH57_04440) 879548..880069 - 522 WP_002916308.1 flavodoxin FldB -
LMH57_RS04445 (LMH57_04445) 880170..881066 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LMH57_RS04450 (LMH57_04450) 881089..881802 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMH57_RS04455 (LMH57_04455) 881808..883541 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T225784 WP_004144731.1 NZ_CP087639:879134-879541 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T225784 NZ_CP121356:730602-730898 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225784 WP_002916312.1 NZ_CP087639:878887-879153 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225784 NZ_CP121356:730900-731295 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References