Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA(toxin) |
| Location | 18091..18683 | Replicon | plasmid pDD02297-2 |
| Accession | NZ_CP087636 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02297 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A2X1Q735 |
| Locus tag | LMH52_RS27805 | Protein ID | WP_040174957.1 |
| Coordinates | 18438..18683 (-) | Length | 82 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LMH52_RS27800 | Protein ID | WP_130946792.1 |
| Coordinates | 18091..18441 (-) | Length | 117 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH52_RS27770 (LMH52_27770) | 14308..14595 | - | 288 | WP_130946786.1 | TrbC/VirB2 family protein | - |
| LMH52_RS27775 (LMH52_27775) | 14592..15242 | - | 651 | WP_130946787.1 | lytic transglycosylase domain-containing protein | - |
| LMH52_RS27780 (LMH52_27780) | 15457..15795 | + | 339 | WP_247473156.1 | helix-turn-helix transcriptional regulator | - |
| LMH52_RS27785 (LMH52_27785) | 15778..16944 | - | 1167 | WP_247473158.1 | MobP1 family relaxase | - |
| LMH52_RS27790 (LMH52_27790) | 16947..17654 | - | 708 | WP_247473110.1 | DNA distortion polypeptide 1 | - |
| LMH52_RS27795 (LMH52_27795) | 17917..18075 | - | 159 | WP_165454637.1 | hypothetical protein | - |
| LMH52_RS27800 (LMH52_27800) | 18091..18441 | - | 351 | WP_130946792.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LMH52_RS27805 (LMH52_27805) | 18438..18683 | - | 246 | WP_040174957.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LMH52_RS27810 (LMH52_27810) | 18980..19411 | - | 432 | WP_247473112.1 | hypothetical protein | - |
| LMH52_RS27815 (LMH52_27815) | 19444..19788 | - | 345 | WP_247473114.1 | hypothetical protein | - |
| LMH52_RS27820 (LMH52_27820) | 19810..20013 | - | 204 | WP_247473116.1 | hypothetical protein | - |
| LMH52_RS27825 (LMH52_27825) | 20060..20248 | - | 189 | WP_159861773.1 | hypothetical protein | - |
| LMH52_RS27830 (LMH52_27830) | 20296..20472 | - | 177 | WP_247473117.1 | hypothetical protein | - |
| LMH52_RS27835 (LMH52_27835) | 21083..21298 | - | 216 | Protein_31 | XRE family transcriptional regulator | - |
| LMH52_RS27840 (LMH52_27840) | 21288..21545 | - | 258 | WP_058998978.1 | hypothetical protein | - |
| LMH52_RS27845 (LMH52_27845) | 21542..22084 | - | 543 | WP_247473119.1 | hypothetical protein | - |
| LMH52_RS27850 (LMH52_27850) | 22172..22696 | - | 525 | WP_247473122.1 | J domain-containing protein | - |
| LMH52_RS27855 (LMH52_27855) | 22806..23027 | + | 222 | WP_130946799.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..31960 | 31960 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9598.36 Da Isoelectric Point: 10.3911
>T225778 WP_040174957.1 NZ_CP087636:c18683-18438 [Klebsiella pneumoniae subsp. pneumoniae]
MGKNDKLLEKFINSKKTFEWTELVVLLSFLGYEKKEMQGSRVRFVHEKYKTIMLHRPHPENHIKGGALKDVKRMLKEEGL
L
MGKNDKLLEKFINSKKTFEWTELVVLLSFLGYEKKEMQGSRVRFVHEKYKTIMLHRPHPENHIKGGALKDVKRMLKEEGL
L
Download Length: 246 bp
>T225778 NZ_CP121355:c5330079-5329657 [Mesorhizobium sp. WSM4906]
ATGATCCTTCTGGACACCAATGTCGTTTCGGAGATGATGAGAGCGGAACCTCATCCCGCAGTTCTTGCTTGGCTGGACAA
TCAGGCCGCCGAAACCCTCTACCTCTCCAGCGTGACACTGGCCGAAATCCTGTTCGGGATAGAGGCGATGCCAGCGGGCC
GCCGTAAGAGCGCCTTGGCTGAAGTCTTTTCGGGCATATTCGCAGTTTTCGACCAGCGCATTCTGGTGCTCGATGTCGAG
GCAGCGCGGCGCTATGCAGGTCTTGCCGTGAAGGCCAGGGCTGCAGGCAAGGGGTTTCCCGTTCCCGATGGGTACATCGC
GGCGATTGCCGCTGCGAAGGGCTTTCAAGTCGCTTCGCGCGACACCGCGCCATTTCACGCCGCCGGCGTGCCGGTCATCA
ATCCGTGGGACAATGCGGCGTAA
ATGATCCTTCTGGACACCAATGTCGTTTCGGAGATGATGAGAGCGGAACCTCATCCCGCAGTTCTTGCTTGGCTGGACAA
TCAGGCCGCCGAAACCCTCTACCTCTCCAGCGTGACACTGGCCGAAATCCTGTTCGGGATAGAGGCGATGCCAGCGGGCC
GCCGTAAGAGCGCCTTGGCTGAAGTCTTTTCGGGCATATTCGCAGTTTTCGACCAGCGCATTCTGGTGCTCGATGTCGAG
GCAGCGCGGCGCTATGCAGGTCTTGCCGTGAAGGCCAGGGCTGCAGGCAAGGGGTTTCCCGTTCCCGATGGGTACATCGC
GGCGATTGCCGCTGCGAAGGGCTTTCAAGTCGCTTCGCGCGACACCGCGCCATTTCACGCCGCCGGCGTGCCGGTCATCA
ATCCGTGGGACAATGCGGCGTAA
Antitoxin
Download Length: 117 a.a. Molecular weight: 13031.72 Da Isoelectric Point: 4.6250
>AT225778 WP_130946792.1 NZ_CP087636:c18441-18091 [Klebsiella pneumoniae subsp. pneumoniae]
MKHLKYKGYLGTVEPDFDNNILYGKLAFIGDLVTYEAETLAELEQEFKTSVDLYLQACAEDGKKPDTPFKGVFNVRVDPD
LHRRIAEMALAEDLSLNAFVNKALEKEVSHNSYGAS
MKHLKYKGYLGTVEPDFDNNILYGKLAFIGDLVTYEAETLAELEQEFKTSVDLYLQACAEDGKKPDTPFKGVFNVRVDPD
LHRRIAEMALAEDLSLNAFVNKALEKEVSHNSYGAS
Download Length: 351 bp
>AT225778 NZ_CP121355:c5330330-5330076 [Mesorhizobium sp. WSM4906]
ATGACTGCTGTAACGATCAGAAATCTTCCGGAAGAGACGCACCGTGCTCTGCGTGTACGCGCGGCCATCAATGGCCGCAG
CACGGAGGCGGAAATCCGCGCCATTCTTGAAGATGCCGTTCGGCCGGAGGGGCGTGTCAAGCTAGGCTCTCTGTTGTCCG
ACATTGCTCGCCGGGCCGGCGTGAAGAACGAGGATGTCGATGCCCTGGAGCAGGCCCTTGGCAAACGCCCCGCCGAACCT
CTGAGCTTTGAATGA
ATGACTGCTGTAACGATCAGAAATCTTCCGGAAGAGACGCACCGTGCTCTGCGTGTACGCGCGGCCATCAATGGCCGCAG
CACGGAGGCGGAAATCCGCGCCATTCTTGAAGATGCCGTTCGGCCGGAGGGGCGTGTCAAGCTAGGCTCTCTGTTGTCCG
ACATTGCTCGCCGGGCCGGCGTGAAGAACGAGGATGTCGATGCCCTGGAGCAGGCCCTTGGCAAACGCCCCGCCGAACCT
CTGAGCTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|