Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5095207..5096888 | Replicon | chromosome |
| Accession | NZ_CP087634 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02297 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | W8V1Q6 |
| Locus tag | LMH52_RS25265 | Protein ID | WP_002885155.1 |
| Coordinates | 5095207..5096124 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | W8UPQ8 |
| Locus tag | LMH52_RS25270 | Protein ID | WP_004151732.1 |
| Coordinates | 5096130..5096888 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH52_RS25245 (LMH52_25245) | 5090513..5092033 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| LMH52_RS25250 (LMH52_25250) | 5092030..5093028 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| LMH52_RS25255 (LMH52_25255) | 5093059..5094000 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| LMH52_RS25260 (LMH52_25260) | 5094075..5095082 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
| LMH52_RS25265 (LMH52_25265) | 5095207..5096124 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LMH52_RS25270 (LMH52_25270) | 5096130..5096888 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| LMH52_RS25275 (LMH52_25275) | 5096974..5097702 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
| LMH52_RS25280 (LMH52_25280) | 5097975..5100122 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
| LMH52_RS25285 (LMH52_25285) | 5100352..5101038 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T225774 WP_002885155.1 NZ_CP087634:c5096124-5095207 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T225774 NZ_CP121355:c2864800-2864411 [Mesorhizobium sp. WSM4906]
GTGATAATCGACTCGTCGGCCCTGGTCGCGATCCTCCGCGCCGAGCCAGGCCATGACCGCTTGGTGCAGGCGATCGCGGA
TGCCGCAAGACGCTTGATTGCTGCGCCAACCCTCCTCGAAACCAGCATGGTGCTCGCCGGTGGATGGCAGGACGAGATCC
TGGACCGGCTCGACGCCTTGCTGCGGACGGCTTCTATCGAGACCGTCGCCTTCACCGCCGACCATGCCGCGGTCGCGCGC
CAAGCCTTCCTGCGCTACGGCAAGGGCCGGCATCCGGCGGCGTTGAACTTCGGCGACTGCATCGCCTATGCGACGGCGCG
GCTCGAAGCGATGCCGCTGCTGTTCAAGGGTGATGATTTCCGGCTGACCGACATCGAACCGGCAATCTGA
GTGATAATCGACTCGTCGGCCCTGGTCGCGATCCTCCGCGCCGAGCCAGGCCATGACCGCTTGGTGCAGGCGATCGCGGA
TGCCGCAAGACGCTTGATTGCTGCGCCAACCCTCCTCGAAACCAGCATGGTGCTCGCCGGTGGATGGCAGGACGAGATCC
TGGACCGGCTCGACGCCTTGCTGCGGACGGCTTCTATCGAGACCGTCGCCTTCACCGCCGACCATGCCGCGGTCGCGCGC
CAAGCCTTCCTGCGCTACGGCAAGGGCCGGCATCCGGCGGCGTTGAACTTCGGCGACTGCATCGCCTATGCGACGGCGCG
GCTCGAAGCGATGCCGCTGCTGTTCAAGGGTGATGATTTCCGGCTGACCGACATCGAACCGGCAATCTGA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT225774 WP_004151732.1 NZ_CP087634:c5096888-5096130 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT225774 NZ_CP121355:c2865063-2864797 [Mesorhizobium sp. WSM4906]
ATGGCGCTCTCGATCAAGAATATGGAGGTCGAGCGGTTGGCGCGGGAGCTTGCCCGTCGCCGTCGCATATCGGTGACGGA
AGCGATCCGTCAAAGCCTCGAGCGCGAGGTGGCGCGCGAGCGGCTGGTGCCTCGCAACGAGAACAGCGACCTTTTCCAAC
GGCTGATGGCAATTTCGGACAGCGCCGCGCAGGTCCCGAAACGGGAAAATGCGATGACCGAGGATGAGATCCTTGGCTAT
GACGAACATGGGGCTCCGACGCGGTGA
ATGGCGCTCTCGATCAAGAATATGGAGGTCGAGCGGTTGGCGCGGGAGCTTGCCCGTCGCCGTCGCATATCGGTGACGGA
AGCGATCCGTCAAAGCCTCGAGCGCGAGGTGGCGCGCGAGCGGCTGGTGCCTCGCAACGAGAACAGCGACCTTTTCCAAC
GGCTGATGGCAATTTCGGACAGCGCCGCGCAGGTCCCGAAACGGGAAAATGCGATGACCGAGGATGAGATCCTTGGCTAT
GACGAACATGGGGCTCCGACGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GH11 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GQB5 |