Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4939023..4939539 Replicon chromosome
Accession NZ_CP087634
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02297

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LMH52_RS24465 Protein ID WP_002886902.1
Coordinates 4939023..4939307 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LMH52_RS24470 Protein ID WP_002886901.1
Coordinates 4939297..4939539 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH52_RS24440 (LMH52_24440) 4934507..4934770 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LMH52_RS24445 (LMH52_24445) 4934900..4935073 + 174 WP_002886906.1 hypothetical protein -
LMH52_RS24450 (LMH52_24450) 4935076..4935819 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LMH52_RS24455 (LMH52_24455) 4936176..4938314 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LMH52_RS24460 (LMH52_24460) 4938555..4939019 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LMH52_RS24465 (LMH52_24465) 4939023..4939307 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMH52_RS24470 (LMH52_24470) 4939297..4939539 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LMH52_RS24475 (LMH52_24475) 4939617..4941527 - 1911 WP_004152270.1 PRD domain-containing protein -
LMH52_RS24480 (LMH52_24480) 4941550..4942704 - 1155 WP_002886900.1 lactonase family protein -
LMH52_RS24485 (LMH52_24485) 4942770..4943510 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T225773 WP_002886902.1 NZ_CP087634:c4939307-4939023 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T225773 NZ_CP121355:2655885-2656271 [Mesorhizobium sp. WSM4906]
GTGATCTATCTGCTCGATACCAATGCTGTCATCGCCGTCATGAAGGGCGATGATGATTTGCTGACAGTGCTCAAGCGAAA
CAAGCCTCAAGATTTCGCGCTTTCGGCAATTGTCGTGCACGAGCTCTATTATGGGGCTTACAGAGGCCAGCGAACGGAAG
AGAATCTCGCACGGCTGGACGCGCTTTTGTTTCCGGTACTCGAATTCGATCGGGAAGACGCGCGGCACGCCGGCGAGATT
CGGGCGATGCTGGCGACATCGGGAACTCCAATTGGTCCCTTTGATGTACTTATTGGAGGCCAGGCACGTGCCCGCGGCCT
GACGTTGATGACGCGGAATGTTCGCGAGTTCGAACGGATCAGGGGTCTGGCGATCGAGACTTGGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT225773 WP_002886901.1 NZ_CP087634:c4939539-4939297 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT225773 NZ_CP121355:2655643-2655888 [Mesorhizobium sp. WSM4906]
ATGAACAAAGCAAAAATATTCTGGTCAGGCCGCTCGCAGGCTGTACGCCTGCCGAAGGAGTTTCGCTTTGAAACTGACGA
GGTTTCGATCCGTCGTCATGGTCAGACTGTCGTTCTTGAACCTCTTCCCCAGGATTGGGCCTGGCTTGATCAGGTGATCG
GGACACTTGACGACGATTTTGTCGATGCGGCGGAGGAAAGGGTAGAGGAGCAAAAACGGCCAGCTCTCGGCGACGTCTTC
AAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References