Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2761108..2762696 | Replicon | chromosome |
| Accession | NZ_CP087634 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain DD02297 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A0H3GN97 |
| Locus tag | LMH52_RS13655 | Protein ID | WP_004199851.1 |
| Coordinates | 2761108..2762430 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | LMH52_RS13660 | Protein ID | WP_002904790.1 |
| Coordinates | 2762430..2762696 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMH52_RS13640 (LMH52_13640) | 2756173..2758674 | + | 2502 | WP_004199853.1 | fimbria/pilus outer membrane usher protein | - |
| LMH52_RS13645 (LMH52_13645) | 2758662..2759666 | + | 1005 | WP_004199852.1 | fimbrial protein | - |
| LMH52_RS13650 (LMH52_13650) | 2759799..2761091 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| LMH52_RS13655 (LMH52_13655) | 2761108..2762430 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LMH52_RS13660 (LMH52_13660) | 2762430..2762696 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| LMH52_RS13665 (LMH52_13665) | 2762962..2763288 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| LMH52_RS13670 (LMH52_13670) | 2763285..2763785 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| LMH52_RS13675 (LMH52_13675) | 2763763..2765142 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
| LMH52_RS13680 (LMH52_13680) | 2765488..2766642 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| LMH52_RS13685 (LMH52_13685) | 2766623..2767546 | - | 924 | WP_004199849.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T225770 WP_004199851.1 NZ_CP087634:c2762430-2761108 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T225770 NZ_CP121354:c5306867-5306445 [Mesorhizobium sp. WSM4904]
ATGATCCTTCTGGACACCAATGTCGTTTCGGAGATGATGAGAGCGGAACCTCATCCCGCAGTTCTTGCTTGGCTGGACAA
TCAGGCCGCCGAAACCCTCTACCTCTCCAGCGTGACACTGGCCGAAATCCTGTTCGGGATAGAGGCGATGCCAGCGGGCC
GCCGTAAGAGCGCCTTGGCTGAAGTCTTTTCGGGCATATTCGCAGTTTTCGACCAGCGCATTCTGGTGCTCGATGTCGAG
GCAGCGCGGCGCTATGCAGGTCTTGCCGTGAAGGCCAGGGCTGCAGGCAAGGGGTTTCCCGTTCCCGATGGGTACATCGC
GGCGATTGCCGCTGCGAAGTGCTTTCAAGTCGCTTCGCGCGACACCGCGCCATTTCACGCCGCCGGCGTGCCGGTCATCA
ATCCGTGGGACAATGCGGCGTAA
ATGATCCTTCTGGACACCAATGTCGTTTCGGAGATGATGAGAGCGGAACCTCATCCCGCAGTTCTTGCTTGGCTGGACAA
TCAGGCCGCCGAAACCCTCTACCTCTCCAGCGTGACACTGGCCGAAATCCTGTTCGGGATAGAGGCGATGCCAGCGGGCC
GCCGTAAGAGCGCCTTGGCTGAAGTCTTTTCGGGCATATTCGCAGTTTTCGACCAGCGCATTCTGGTGCTCGATGTCGAG
GCAGCGCGGCGCTATGCAGGTCTTGCCGTGAAGGCCAGGGCTGCAGGCAAGGGGTTTCCCGTTCCCGATGGGTACATCGC
GGCGATTGCCGCTGCGAAGTGCTTTCAAGTCGCTTCGCGCGACACCGCGCCATTTCACGCCGCCGGCGTGCCGGTCATCA
ATCCGTGGGACAATGCGGCGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT225770 WP_002904790.1 NZ_CP087634:c2762696-2762430 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT225770 NZ_CP121354:c5307118-5306864 [Mesorhizobium sp. WSM4904]
ATGACTGCTGTAACGATCAGAAATCTTCCGGAAGAGACGCACCGTGCTCTGCGTGTACGCGCGGCCATCAATGGCCGCAG
CACGGAGGGGGAAATCCGCGCCATTCTTGAAGATGCCGTTCGGCCGGAGGGGCGTGTCAAGCTAGGCTCTCTGTTGTCCG
ACATTGCTCGCCGGGCCGGCGTGAAGAACGAGGATGTCGATGCCCTGGAGCAGGCCCTTGGCAAACGCCCCGCCGAACCT
CTGAGCTTTGAATGA
ATGACTGCTGTAACGATCAGAAATCTTCCGGAAGAGACGCACCGTGCTCTGCGTGTACGCGCGGCCATCAATGGCCGCAG
CACGGAGGGGGAAATCCGCGCCATTCTTGAAGATGCCGTTCGGCCGGAGGGGCGTGTCAAGCTAGGCTCTCTGTTGTCCG
ACATTGCTCGCCGGGCCGGCGTGAAGAACGAGGATGTCGATGCCCTGGAGCAGGCCCTTGGCAAACGCCCCGCCGAACCT
CTGAGCTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GN97 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |