Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 860443..861097 Replicon chromosome
Accession NZ_CP087634
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02297

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag LMH52_RS04320 Protein ID WP_004144731.1
Coordinates 860690..861097 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LMH52_RS04315 Protein ID WP_002916312.1
Coordinates 860443..860709 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH52_RS04290 (LMH52_04290) 855599..857032 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LMH52_RS04295 (LMH52_04295) 857151..857879 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LMH52_RS04300 (LMH52_04300) 857929..858240 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LMH52_RS04305 (LMH52_04305) 858404..859063 + 660 WP_002916317.1 hemolysin III family protein -
LMH52_RS04310 (LMH52_04310) 859214..860197 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LMH52_RS04315 (LMH52_04315) 860443..860709 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LMH52_RS04320 (LMH52_04320) 860690..861097 + 408 WP_004144731.1 protein YgfX Toxin
LMH52_RS04325 (LMH52_04325) 861104..861625 - 522 WP_002916308.1 flavodoxin FldB -
LMH52_RS04330 (LMH52_04330) 861726..862622 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LMH52_RS04335 (LMH52_04335) 862645..863358 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMH52_RS04340 (LMH52_04340) 863364..865097 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T225761 WP_004144731.1 NZ_CP087634:860690-861097 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T225761 NZ_CP121344:c2043844-2043545 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCCGTAGTC
GTGAGGAAATTCGCTTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT225761 WP_002916312.1 NZ_CP087634:860443-860709 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT225761 NZ_CP121344:c2044074-2043841 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAGAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References