Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 102486..103156 Replicon plasmid pDD02341-2
Accession NZ_CP087631
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02341

Toxin (Protein)


Gene name vagD Uniprot ID Q6U619
Locus tag LMH53_RS28380 Protein ID WP_004213072.1
Coordinates 102486..102929 (-) Length 148 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q6U620
Locus tag LMH53_RS28385 Protein ID WP_004213073.1
Coordinates 102926..103156 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH53_RS28345 (LMH53_28345) 97894..98169 + 276 WP_004213932.1 carboxymuconolactone decarboxylase family protein -
LMH53_RS28350 (LMH53_28350) 98232..98723 + 492 WP_011251327.1 DM13 domain-containing protein -
LMH53_RS28355 (LMH53_28355) 98772..99692 + 921 WP_004213934.1 DUF1471 domain-containing protein -
LMH53_RS28360 (LMH53_28360) 99783..100186 + 404 Protein_108 GAF domain-containing protein -
LMH53_RS28365 (LMH53_28365) 100703..101341 - 639 WP_032488580.1 mucoid phenotype regulator RmpA2 -
LMH53_RS28370 (LMH53_28370) 101759..102063 + 305 Protein_110 transposase -
LMH53_RS28375 (LMH53_28375) 102086..102337 - 252 WP_186987481.1 hypothetical protein -
LMH53_RS28380 (LMH53_28380) 102486..102929 - 444 WP_004213072.1 type II toxin-antitoxin system VapC family toxin Toxin
LMH53_RS28385 (LMH53_28385) 102926..103156 - 231 WP_004213073.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LMH53_RS28390 (LMH53_28390) 103764..104897 + 1134 WP_004213075.1 DUF3800 domain-containing protein -
LMH53_RS28395 (LMH53_28395) 104913..105206 + 294 WP_004213076.1 hypothetical protein -
LMH53_RS28400 (LMH53_28400) 105196..105402 - 207 WP_004213077.1 hypothetical protein -
LMH53_RS28405 (LMH53_28405) 105754..106044 + 291 WP_004213078.1 hypothetical protein -
LMH53_RS28410 (LMH53_28410) 106034..106933 + 900 WP_004225022.1 nucleotide-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iucA / iucB / iucC / iucD / iutA / rmpA 1..178159 178159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 148 a.a.        Molecular weight: 16006.74 Da        Isoelectric Point: 9.3642

>T225752 WP_004213072.1 NZ_CP087631:c102929-102486 [Klebsiella pneumoniae subsp. pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS

Download         Length: 444 bp

>T225752 NZ_CP121298:c4390879-4390592 [Salmonella enterica subsp. enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT225752 WP_004213073.1 NZ_CP087631:c103156-102926 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT225752 NZ_CP121298:c4390605-4390303 [Salmonella enterica subsp. enterica]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q6U619


Antitoxin

Source ID Structure
AlphaFold DB Q6U620

References